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OMV-specific IgG antibody responses in serum measured by enzyme-linked immunosorbent assay for 10 adult vaccinees given three doses of OMV vaccine at weeks 0, 6, and 46. Data are expressed as maximum responses obtained 1, 2, or 6 weeks after each dose given. Boxes extend from the 25th to the 75th percentile, with a horizontal line at the median. Vertical bars show the range of the data. Significant responses after vaccination were observed after each immunization (P = 0.002).
