Figure 4.

Performance of the UK Biobank Cardiovascular disease Risk Prediction (UKCRP) and subgroup analysis. (A) Area under the receiver operating characteristic curve (AUC) plots of different models of cardiovascular disease. (B) AUC of different models evaluated on different diagnostic subgroups. (C) AUC of the UKCRP that evaluated based on different age subgroups. (D) AUC of the UKCRP that evaluated based on different incident time subgroups. (E–H) Calibration plots of UKCRP on different diagnostic populations. Specific isotonic regressions were trained for each population. AHA/ASCVD, American Heart Association/Atherosclerotic Cardiovascular Disease; FGCRS, Framingham Cardiovascular Risk Score; HS, haemorrhagic stroke; IS, ischaemic stroke; MI, myocardial infarction; PRS, polygenic risk score; QRISK V.3, a cardiovascular disease risk score derived through QResearch database V.3; SCORE V.2, Systematic Coronary Risk Evaluation V.2.