Figure 4.

Single-FC dysfunction and network-FC dysfunction within the right-thalamus network. Among the 90 AAL regions, the right thalamus has the highest number of significantly different pair-wise functional connectivity (FC) between schizophrenia and control groups. (A) Brain regions connected to the right thalamus are presented in a clockwise arrangement according to the number of interconnections within the right thalamus network. (R, right, L, left, Ant, anterior, Sup, superior, Mid, middle, Inf, inferior, Oper, opercular). (B,C) Brain regions connected to the right thalamus (B) and bilateral thalamus (C) that do not have interconnections within the thalamus network are depicted as single-FC dysfunction regions. Conversely, brain regions connected to the right thalamus (B) and bilateral thalamus (C) that exhibit additional interconnections within the thalamus network are depicted as network-FC dysfunction regions. Within the thalamus network, FCs of brain regions having direct connections to the thalamus were all increased, but FCs without direct connections to the thalamus were all decreased. Brain regions are represented by abbreviations of the AAL-90 atlas (Supplementary Table S1).