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. 2024 Jan 8;15:1306496. doi: 10.3389/fnagi.2023.1306496

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Copyright © 2024 Gandy, Hollis, Hernandez and McQuail.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age-related impairment of mPFC-dependent working memory. (A) Choice accuracy (y-axis) as a function delay (x-axis) of aged (filled circles, n = 14) is significantly worse than to young adults (open circles, n = 10) in a manner than interacts with delay (age: p < 0.001; interaction: p < 0.001). (B) Choice accuracy (averaged across 8, 12, 18, and 24 s delays; left y-axis) of individual young and aged rats; estimation plot of change (Δ) in mean choice accuracy between young and aged (in red; p < 0.001; right axis). (C) Trials completed (left y-axis) by individual young and aged rats; estimation plot of change (Δ) in trials completed between young and aged (in red; p < 0.001; right axis).