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Attachment of B. burgdorferi to neural cells is mediated by both heparinase- and chondroitinase ABC-sensitive proteoglycans. Attachment of N40 to primary rat telencephalic cells (43) (A) or the mouse midbrain neuronal cell line CATH.a (41) (B) was assessed in assays using exogenous proteoglycans, platelet factor 4, chlorate inhibition of proteoglycan sulfation, or lyase digestion of glycosaminoglycans as described in the legend to Fig. 1.
