TABLE 3.
Mean antimalarial activities and cytotoxicities for AD01, PhX6, DpNEt and artemisone in vitro with associated controls, n = 3.
| Compound | Plasmodium falciparum IC50 (nM) | Chinese hamster ovary IC50 (µM) | Resistance index a | Selectivity index+ | ||
|---|---|---|---|---|---|---|
| NF54 | DD2 | CHO/sensitive Pf strain | CHO/resistant Pf strain | |||
| AD01 | 23.1 ± 2.5 | 11.9 ± 2.8 | 74 ± 9.4 | 0.5 | >1,000 | >1,000 |
| PhX6 | 41.8 ± 0.04 | 16.2 ± 2.4 | 192 ± 4.6 | 0.4 | >1,000 | >1,000 |
| DpNEt | 40.7 ± 1.4 | 28.6 ± 4.0 | 11 ± 4.2 | 0.7 | 270 | 384 |
| AMS | 4.50 ± 2.42 | 5.48 ± 2.03 | >249 ± ND | 1.2 | >1,000 | >1,000 |
| CQ | 9.9 ± 0.4 | 142 ± 16.8 | ND | 14.3 | ND | ND |
a
Resistance index = IC50 (resistant strain)/IC50 (sensitive strain), + Selectivity Index = cytotoxicity IC50/activity IC50; ND, not determined; CHO, chinese hamster ovary; AMS, artemisone; CQ, chloroquine.