Table 2.

The TLS (-/+) relationship with the clinical pathological parameters.

Characteristics		patients	TLS		χ2	P value
		(n=198)	-	+
Gender
	Male	87	26	61	2.408	0.121
	Female	111	45	66
Age (Median)
	≤64	115	45	70	1.277	0.258
	>64	83	26	57
Tumor size (Median)
	≤2.0	115	49	66	5.435	0.020
	>2.0	83	22	61
cTNM
	I	130	55	75	7.101	0.029
	II	34	9	25
	III	34	7	27
Pathological grades (adenocarcinoma)
	Poorly differentiated	35	27	8	31.697	<0.001
	Moderately differentiated	99	28	71
	Highly differentiated	64	16	48
Lymphatic metastasis
	Yes	34	7	27	4.162	0.041
	No	164	64	100
Pleural Invasion
	Yes	25	7	18	0.768	0.381
	No	173	64	109
Vascular invasion
	Yes	53	9	44	11.425	< 0.001
	No	145	62	83
Nerve invasion
	Yes	10	4	6	0.003	0.954
	No	188	67	121

The bold values denote statistical significance at P<0.05 level.