Table 3.

The TLS density relationship with the clinical pathological parameters.

Characteristics		patients	TLS density		χ2	P value
		(n=127)	Low	High
Gender
	Male	61	34	27	0.419	0.518
	Female	66	33	33
Age (Median)
	≤64	70	38	32	0.146	0.702
	>64	57	29	28
Tumor size (Median)
	≤2.0	66	38	28	1.281	0.258
	>2.0	61	29	32
cTNM
	I	75	42	33	8.560	0.014
	II	25	7	18
	III	27	18	9
Pathological grades (adenocarcinoma)
	Poorly differentiated	8	7	1	4.224	0.121
	Moderately differentiated	71	35	36
	Highly differentiated	48	25	23
Lymphatic metastasis
	Yes	27	14	13	0.011	0.916
	No	100	53	47
Pleural Invasion
	Yes	18	9	9	0.064	0.800
	No	109	58	51
Vascular invasion
	Yes	44	24	20	0.079	0.799
	No	83	43	40
Nerve invasion
	Yes	7	4	3	0.001	0.980
	No	120	68	52
CD8 within TLS
	Low	73	66	7	97.67	<0.0001
	High	54	1	53

The bold values denote statistical significance at P<0.05 level.