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. 2024 Jan 8;10:1323760. doi: 10.3389/fcvm.2023.1323760

Figure 4.

Figure 4

Deletion of TFEB improves cardiac function in pressure overload-induced HFrEF. (A) Kinetics of left ventricular ejection fraction (LVEF), fractional shortening (FS), stroke volume (SV), and cardiac output (CO) as determined at indicated time points after Sham and TAC surgery, respectively, of WT and cKO mice (* = WT_TAC/WT_Sham, “ = cKO_TAC/cKO_Sham, & = cKO_TAC/WT_TAC). (B) Cardiac function as measured in (A) after 56 days of Sham or TAC treated WT and cKO mice. (C) Heart, lung, and liver weights of WT and cKO mice after 56 days of Sham or TAC surgery, normalized to tibia length. (D) Wheat Germ Agglutinin (WGA) stained histological cross-sections of hearts from WT and cKO mice after 56 days of Sham or TAC surgery. (E) Myocyte cross-sectional area (MCSA) measured from on WGA stained sections with Image J. Scale bar, 100 µm. Data are presented as mean ± SD (56 days, WT Sham: n = 10, WT TAC: n = 6, cKO Sham: n = 8, cKO TAC: n = 6; *,”,&q < 0.05, **q < 0.01, ***q < 0.001, ****q < 0.0001).