AI	Artificial intelligence
AKI	Acute kidney injury
B3C	Blood-brain-barrier on-a-chip
C5	Complement 5
CAMs	Cell adhesion molecules
CD64	Cluster of differentiation 64
CRP	C-reactive protein
CS	Chondroitin sulphate
CXCL8	C-X-C motif chemokine ligand 8
DAMPs	Damage-associated molecular patterns
DEGs	Differentially expressed genes
ECs	Endothelial cells
eGC	Endothelial glycocalyx
ESAM	Endothelial cell-selective adhesive molecules
EVs	Extracellular vesicles
FDA	Food and Drug Administration
fMLP	N-Formylmethionyl-leucyl-phenylalanine
GO BP	Gene Ontology Biological Process
H2O2	Hydrogen peroxide
HA	Hyaluronan
HBMVEC	Human brain microvascular endothelial cell
HLA	Major histocompatibility complex
HLA-DMA	Major histocompatibility complex, class II, DM alpha
HOCl	Hypochlorous acid
HS	Heparan sulphaste
Hypoxia-inducible factor-1	hypoxia-inducible factor-1
ICAM-1	Intercellular adhesion molecule 1
IFI6	Interferon alpha inducible protein 6
IFIT1	Interferon induced protein with tetracopeptide repeats 1
IFN-γ	Interferon-gamma
IL-15	Interleukin-15
IL-1β	Interleukin-1 beta
IL-6	Interleukin-6
IL-8	Interleukin-8
JAMs	Junctional adhesion molecule
LAT	Linker for activation of T cells
LBP	Lipopolysaccharide binding protein
MARS	Molecular Diagnosis and Risk Stratification of Sepsis
MCP-1	Monocyte chemoattractant protein 1
miRNA	Micro-RNAs
ML	Machine learning
MMP25	Matrix metalloproteinase 25
MMP8	Matrix metalloproteinase 8
MMP9	Matrix metalloproteinase 9
MODS	Multiple organ dysfunction syndrome
MPO	Myeloperoxidase
NADPH	Nicotinamide adenine dinucleotide phosphate
NETs	Neutrophil extracellular traps
NF-κB	Nuclear factor-kappa beta
NFKBIA	Nuclear factor kappa beta inhibitor alpha
NPMODS	New or progressive multiple organ dysfunction syndrome
O2 -	Superoxide anion
OH•	Hydroxide free radical
PAMPs	Pathogen-associated molecular patterns
PCT	Procalcitonin
PD-L1	Programmed cell death ligand 1
PECAM-1	Platelet-endothelial cell adhesion molecule 1
PKCδ	Protein Kinase C-delta
PPI	Protein-protein interaction
PRRs	Pattern recognition receptors
rhTM	Recombinant human thrombomodulin therapy
RNA-seq	RNA-sequencing
ROS	Reactive oxygen species
SDC-1	Syndecan-1
sTREM-1	Soluble-triggering receptor expressed on myeloid cells-1
TNF-α	Tumor necrosis factor-alpha
TRAT	T-cell receptor-associated transmembrane adapter 1
VCAM-1	Vascular cell adhesion molecule 1
WGCNA	Weighted gene correlation network analysis
WHO	World Health Organization