Table 3.
Treatment response to anti-IL1 drugs in PAMI syndrome.
| ID article (IDPatient)/Cycles | Syndrome | DRUG/DOSE-duration | Previous treatment | Concomitant treatment | Clinical efficacy | Efficacy 6-12 weeks/12-24 weeks/>24 weeks/ |
Adverse events/Recurrence | ||
|---|---|---|---|---|---|---|---|---|---|
| Acne | PG | PA | |||||||
| 21 (5)/1 | PAMI | Canakinumab 300mg every 4 weeks | Prednisolone, topical tacrolimus, infliximab, Secukinumab, prednisone and isotretinoin | Corticosteroids, cyclosporine | NA | NA | NA | No | NA |
| 3 months | No | NA | |||||||
| NA | |||||||||
| 23 (6)/1 | PAMI | NA | NA | NA | NA | NA | NA | NA | NA |
| 31 (8)/1 | PAMI | Anakinra | Infliximab, tocilizumab, HD IVIG, corticosteroids, ruxolitinib, rituximab, cyclophosphamide | NA | – | – | NA | NA | NA |
| 31 (9)/1 | PAMI | Anakinra | NA | NA | – | – | – | NA | NA |
| 31 (9)/1 | Canakinumab | NA | NA | – | – | – | NA | NA | |
| 31 (10)/1 | PAMI | Anakinra | Etanercept, infliximab, corticosteroids | NA | – | – | NA | NA | NA |
| 33 (11)/1 | PAMI | Canakinumab 2mg/kg/month and 4mg/kg/month | Antibiotics, corticosteroids, IVIG, colchicine, | Cyclosporine | NA | – | Yes (c) | Yes | No |
| Yes | No | ||||||||
| Yes (2 years) | |||||||||
| 34 (12)/1 | PAMI | Anakinra | Intra-articular steroids inyections, antibiotics, adalimumab, colchicine | NA | Yes (c) | Yes (c) | NA | Yes | NA |
| 2 year | NA | NA | |||||||
| NA | Poor compliance | ||||||||
| 34 (12)/2 | Canakinumab | Intra-articular steroids inyections, antibiotics, adalimumab, colchicine, anakinra | Corticosteroids | Yes (p) | Yes (p) | NA | Yes | Proteinuria | |
| Yes | Flares of acne and PG | ||||||||
| Yes | |||||||||
| 34 (12)/3 | Canakinumab 150mg monthly | Intra-articular steroids inyections, antibiotics, adalimumab, colchicine, anakinra, corticosteroids, tacrolimus | Tacrolimus | Yes (p) | Yes (p) | NA | Yes | NA | |
| 1 year | Corticosteroids | Yes | NA | ||||||
| Yes | |||||||||
| 35 (13)/1 | PAMI | Anakinra 3mg/kg once daily | NA | NA | NA | NA | NA | Yes | Mild transient urticarial skin reaction at the injection site |
| 6 months | Yes | No | |||||||
| Yes (6 months) | |||||||||
PA, pyogenic arthritis; A, acne; PG, pyoderma gangrenosusm; NA, not available; -, not applicable; NSAID, Non-steroidal anti-inflammatory drugs; c, complete (dark green colour); p, partial (green light colour). Partial (p) and Complete (c ). Response to treatment are terms defined by the original studies.