Table 2.

Heterogeneity and pleiotropy analysis of obesity with hypothyroidism using different analytical methods.

Exposure traits	Outcome traits	MR methods	Cochran Q statistic	Heterogeneity p-value	Directional horizontal pleiotropy p-value
BMI	hypothyroidism	IVW	592.9039	<0.001	0.6716
	hypothyroidism/myxededma	IVW	842.0871	<0.001	0.3442
WC	hypothyroidism	IVW	56.2699	0.0169	0.3552
	hypothyroidism/myxededma	IVW	82.2342	<0.001	0.2545
WCadjBMI	hypothyroidism	IVW	85.5966	0.0107	0.2705
	hypothyroidism/myxededma	IVW	127.5437	<0.001	0.7382

BMI, Body mass index; WC, Waist circumference; WCadjBMI, Waist circumference adjusted for BMI; MR, Mendelian Randomization; IVW, Inverse variance weighted.