Table 3.
Heterogeneity and pleiotropy analysis of hypothyroidism with obesity using different analytical methods.
| Exposure traits | Outcome traits | MR methods | Cochran Q statistic | Heterogeneity p-value | Directional horizontal pleiotropy p-value |
|---|---|---|---|---|---|
| hypothyroidism | BMI | IVW | 75.1653 | <0.001 | 0.6112 |
| WC | IVW | 32.3268 | 0.1488 | 0.3659 | |
| WCadjBMI | IVW | 41.0647 | 0.0226 | 0.2161 | |
| hypothyroidism/myxededma | BMI | IVW | 215.9188 | <0.001 | 0.3627 |
| WC | IVW | 75.5121 | 0.0509 | 0.0344 | |
| WCadjBMI | IVW | 98.3950 | <0.001 | 0.3410 |
BMI, Body mass index; WC, Waist circumference; WCadjBMI, Waist circumference adjusted for BMI; MR, Mendelian Randomization; IVW, Inverse variance weighted.