Table 1.
Sensitivity Analyses for Survival Among Children With Inborn Errors of Metabolism Treated With Kidney Replacement Therapy
| Criteria | Number of Studies (n) | Number of Children (n) | % Proportion (95% CI) | I2 (95% CI); P value | Egger’s Test P Value |
|---|---|---|---|---|---|
| Overall | 14 | 231 | 63.4 (52.4-73.7) | 63.2% (34.5%-79.3%); P < 0.001 | 0.31 |
| Age (>0.7 ya) | 7 | 96 | 59.8 (38.5-79.3) | 78.4% (55.4%-89.6%); P < 0.001 | 0.19 |
| Sample size (>15a) | 6 | 162 | 50.9 (35.8-65.9) | 74.3% (41.4%-88.7%); P = 0.002 | 0.08 |
| Geography (United States) | 5 | 105 | 59.2 (49.4-68.5) | 57.7% (20.0%-80.8%); P = 0.01 | 0.77 |
| Study Quality (Good) | 12 | 192 | 62.3 (49.4-74.4) | 67.1% (39.7%-82.1%); P < 0.001 | 0.30 |
Note: Values were reported either as mean, median, or range; range was converted into mean by averaging min and max values.
Abbreviations: CI, confidence interval.
a
Median across the studies.