Table 1.
Clinical cases showing blood creatinine concentrations against patient emergency pharmacotherapy timeframe.
| Hospital Department, where the adverse event was detected | Patient/date | CREP2 (μmol/l) | CREJ2 (μmol/l) | Relevant medications (active substances) from patient discharge summaries (dosage unavailable) and/or daily medication cards (dosage available) |
|---|---|---|---|---|
| 1 (LR) | CREP2 | CREJ2 | ||
| Department of Surgery | 10 January 2023 12 January 2023 14 January 2023 15 January 2023 16 January 2023 17 January 2023 18 January 2023 19 January 2023 20 January 2023 |
186 | N/A | Paracetamol 1 g orally every 8 h |
| 201 | N/A | |||
| 131 | N/A | |||
| 187 | 325 | |||
| 261 | 355 | |||
| 304 | 311 | |||
| 294 | 288 | |||
| 289 | N/A | |||
| 257 | 254 | |||
| 2 (NN) | CREP2 | CREJ2 | ||
| Department of Surgery | 11 January 2023 12 January 2023 13 January 2023 14 January 2023 15 January 2023 16 January 2023 |
81 | N/A | Paracetamol 1 g/100 mL i.v. every 8 h (20 min), etamsylate 500 mg i.v. every 8 h |
| 92 | N/A | |||
| 34 | N/A | |||
| 61 | 87 | |||
| 90 | 86 | |||
| 106 | 98 | |||
| 3 (AE) | CREP2 | CREJ2 | ||
| Department of Surgery | 15 January 2023 16 January 2023 17 January 2023 24 January 2023 |
124 | 264 | Paracetamol, metamizole, etamsylate 500 mg i.v. every 4 h |
| 127 | 220 | |||
| 89 | 177 | |||
| 135 | 130 | |||
| 4 (KL) | CREP2 | CREJ2 | ||
| Department of Surgery | 13 January 2023 14 January 2023 15 January 2023 16 January 2023 17 January 2023 18 January 2023 19 January 2023 20 January 2023 21 January 2023 22 January 2023 |
209 | N/A | Etamsylate, noradrenalin continuous, paracetamol i.v., metamizole i.v. |
| 125 | N/A | |||
| 108 | 193 | |||
| 124 | 215 | |||
| 154 | 264 | |||
| 188 | 308 | |||
| 243 | N/A | |||
| 305 | 376 | |||
| 334 | 353 | |||
| 351 | 365 | |||
| 5 (LN) | CREP2 | CREJ2 | ||
| Department of Infectious Diseases | 15 January 2023 16 January 2023 19 January 2023 20 January 2023 21 January 2023 |
223 | 330 | Metamizole, noradrenalin |
| 250 | 318 | |||
| 232 | N/A | |||
| 220 | 219 | |||
| 210 | 227 | |||
| 6 (AA) | CREP2 | CREJ2 | ||
| Department of Anaestesiology and Intensive Care Medicine | 10 January 2023 11 January 2023 12 January 2023 |
117 | N/A | Etamsylate 500 mg i.v. every 6 h acetylcysteine inj. 300 mg i.v. every 12 h |
| 109 | N/A | |||
| 87 | N/A | |||
| 13 January 2023 14 January 2023 15 January 2023 16 January 2023 17 January 2023 18 January 2023 |
67 | N/A | Noradrenalin 5 mg / 50 mL i.v. paracetamol 1 g i.v. 100 mL (20 min) every 6 h metamizole 1 g/20 mL (30 min) | |
| 33 | N/A | |||
| 59 | 80 | |||
| 59 | 65 | |||
| 67 | 55 | |||
| 70 | 61 | |||
| 7 (AH) | CREP2 | CREJ2 | ||
| Department of Pulmonary Diseases and Tuberculosis | 11 January 2023 13 January 2023 15 January 2023 |
240 | N/A | Etamsylate, paracetamol |
| 231 | N/A | |||
| 54 | 131 | |||
| 8 (NN) | CREP2 | CREJ2 | ||
| Department of Internal Medicine and Cardiology | 14 January 2023 15 January 2023 16 January 2023 18 January 2023 21 January 2023 |
184 | N/A | Metamizole |
| 172 | 248 | |||
| 212 | 210 | |||
| 133 | 127 | |||
| 147 | 170 | |||
| 9 (YN) | CREP2 | CREJ2 | ||
| Referred from another hospital | 10 January 2023 11 January 2023 12 January 2023 15 January 2023 |
307 | N/A | Etamsylate administered before patient transportation |
| 377 | N/A | |||
| 347 | N/A | |||
| 233 | 354 | |||
| 10 (KI) | CREP2 | CREJ2 | ||
| Department of Burns and Plastic Surgery | 10 January 2023 16 January 2023 17 January 2023 22 January 2023 27 January 2023 |
62 | N/A | Etamsylate, noradrenalin, metamizole, paracetamol |
| 36 | 54 | |||
| 39 | 50 | |||
| 44 | 53 | |||
| 54 | 52 | |||
| 11 (AVA) | CREP2 | CREJ2 | ||
| Department of Internal Medicine, Hematology and Oncology | 14 January 2023 15 January 2023 16 January 2023 17 January 2023 19 January 2023 23 January 2023 |
51 | N/A | Metamizole 500 mg orally every 8 h |
| 35 | 45 | |||
| 26 | 42 | |||
| 35 | 30 | |||
| 46 | N/A | |||
| 43 | 35 | |||
| 12 (KF) | CREP2 | CREJ2 | ||
| Department of Neurosurgery | 16 January 2023 17 January 2023 18 January 2023 19 January 2023 20 January 2023 |
50 | 100 | Etamsylate |
| 73 | 85 | |||
| 74 | 77 | |||
| 77 | N/A | |||
| 86 | 79 | |||
| 13 (KRT) | CREP2 | CREJ2 | ||
| Department of Anaestesiology and Intensive Care Medicine | 14 January 2023 15 January 2022 16 January 2022 17 January 2023 18 January 2023 19 January 2023 |
97 | N/A | Etamsylate 500 mg i.v. every 6 h, noradrenalin 5 mg/50 mL i.v., paracetamol 1 g/100 mL i.v. (30 min) as needed |
| 100 | 119 | |||
| 86 | 161 | |||
| 137 | 132 | |||
| 130 | 123 | |||
| 105 | N/A | |||
| 14 (KL) | CREP2 | CREJ2 | ||
| Department of Geriatric Medicine | 15 January 2023 16 January 2023 17 January 2023 18 January 2023 20 January 2023 23 January 2023 |
159 | 152 | Etamsylate |
| 116 | 209 | |||
| 96 | 102 | |||
| 157 | 161 | |||
| 113 | 92 | |||
| 107 | 83 | |||
| 15 (LN) | CREP2 | CREJ2 | ||
| Department of Internal Medicine and Cardiology | 10 January 2023 11 January 2023 12 January 2023 13 January 2023 14 January 2023 15 January 2023 16 January 2023 17 January 2023 |
343 | N/A | Metamizole, tramadol/paracetamol, acetylcysteine |
| 386 | N/A | |||
| 430 | N/A | |||
| 467 | N/A | |||
| 419 | N/A | |||
| 396 | 398 | |||
| 365 | 397 | |||
| 276 | 370 | |||
| 16 (AA) | CREP2 | CREJ2 | ||
| 10 January 2023 17 January 2023 24 January 2023 |
47 | N/A | Not accessible | |
| 41 | 61 | |||
| 43 | 54 | |||
| 17 (KD) | CREP2 | CREJ2 | ||
| Department of Neurology | 14 January 2023 17 January 2023 |
102 | N/A | Etamsylate |
| 51 | 82 | |||
| 18 (ATA) | ||||
| Department of Burns and Plastic Surgery | 12 January 2023 12 January 2023 14 January 2023 17 January 2023 18 January 2023 18 January 2023 19 January 2023 23 January 2023 26 January 2023 |
62 | N/A | Not accessible |
| 37 | N/A | |||
| 47 | N/A | |||
| 49 | 45 | |||
| 8 | 73 | |||
| 36 | 52 | |||
| 46 | N/A | |||
| 56 | 47 | |||
| 64 | N/A | |||
| 19 (OJ) | CREP2 | CREJ2 | ||
| Department of Neurology | 17 January 2023 18 January 2023 21 January 2023 |
100 | 108 | Metamizole, paracetamol, etamsylate |
| 56 | 103 | |||
| 48 | 92 | |||
| 20 (AVA) | CREP2 | CREJ2 | ||
| Department of Urology | 18 January 2023 19 January 2023 |
79 | 68 | Etamsylate, metamizole, paracetamol |
| 36 | 75 | |||
| 21 (SI) | CREP2 | CREJ2 | ||
| Department of Urology | 18 January 2023 19 January 2023 23 January 2023 |
106 | 97 | Metamizole, etamsylate, paracetamol |
| 68 | 119 | |||
| 90 | 87 | |||
| 23 (IN) | CREP2 | CREJ2 | ||
| Department of Burns and Plastic Surgery | 13 January 2023 14 January 2023 15 January 2023 |
45 | N/A | |
| 60 | N/A | |||
| 54 | 52 | |||
| 17 January 2023 19 January 2023 20 January 2023 22 January 2023 27 January 2023 |
45 | 49 | Not accessible | |
| 28 | 49 | |||
| 36 | 42 | |||
| 22 | 45 | |||
| 45 | 43 | |||
| 24 (YK) | CREP2 | CREJ2 | ||
| Department of Burns and Plastic Surgery | 13 January 2023 16 January 2023 18 January 2023 19 January 2023 20 January 2023 23 January 2023 24 January 2023 25 January 2023 27 January 2023 |
68 | N/A | Not accessible |
| 59 | 68 | |||
| 52 | 77 | |||
| 65 | N/A | |||
| 39 | 69 | |||
| 84 | 85 | |||
| 69 | 68 | |||
| 56 | 46 | |||
| 49 | 47 | |||
| 25 (KL) | CREP2 | CREJ2 | ||
| Department of Neurosurgery | 18 January 2023 20 January 2023 21 January 2023 21 January 2023 22 January 2023 23 January 2023 24 January 2023 25 January 2023 |
95 | 84 | Etamsylate, acetylcysteine, paracetamol |
| 77 | 118 | |||
| 94 | 98 | |||
| 91 | 92 | |||
| 102 | 98 | |||
| 81 | 83 | |||
| 107 | 93 | |||
| 91 | 84 | |||
| 26 (LLF) | CREP2 | CREJ2 | ||
| Department of Internal Medicine and Gastroenterology | 18 January 2023 19 January 2023 20 January 2023 21 January 2023 22 January 2023 23 January 2023 24 January 2023 |
406 | 358 | Etamsylate |
| 276 | N/A | |||
| 284 | 431 | |||
| 273 | 448 | |||
| 267 | 448 | |||
| 345 | 415 | |||
| 391 | 379 | |||
| 27 (SN) | CREP2 | CREJ2 | ||
| Department of Internal Medicine and Gastroenterology | 18 January 2023 19 January 2023 20 January 2023 21 January 2023 22 January 2023 23 January 2023 24 January 2023 25 January 2023 26 January 2023 27 January 2023 |
74 | 81 | Polymedication including terlipressin acetate |
| 69 | N/A | |||
| 48 | 78 | |||
| 59 | 67 | |||
| 38 | 85 | |||
| 79 | 81 | |||
| 102 | 87 | |||
| 102 | 103 | |||
| 95 | N/A | |||
| 89 | 83 | |||
| 28 (YEL) | CREP2 | CREJ2 | ||
| Department of Urology | 20 January 2023 (11:43) 20 January 2023 (17:05) 21 January 2023 22 January 2023 23 January 2023 |
442 | 640 | |
| 362 | 583 | |||
| 304 | 587 | |||
| 263 | 492 | |||
| 228 | 324 | |||
| Department of Surgery | 24 January 2023 (5:05) 24 January 2023 (17:08) 25 January 2023 26 January 2023 27 January 2023 28 January 2023 29 January 2023 |
294 | 333 | Etamsylate 500 mg i.v. every 6 h, metamizole every 8 h |
| 317 | 379 | |||
| 330 | 355 | |||
| 366 | N/A | |||
| 429 | 429 | |||
| 462 | 474 | |||
| 494 | 496 | |||
| 29 (PŘI) | CREP2 | CREJ2 | ||
| Department of Neurosurgery | 20 January 2023 21 January 2023 22 January 2023 (6:07) 22 January 2023 (9:35) 23 January 2023 24 January 2023 25 January 2023 |
94 | 100 | Metamizole 500 mg every 12 h, etamsylate |
| 80 | 88 | |||
| 42 | 85 | |||
| 82 | 113 | |||
| 67 | 112 | |||
| 49 | 98 | |||
| 100 | 96 | |||
| 30 (ATA) | CREP2 | CREJ2 | ||
| 21 January 2023 22 January 2023 23 January 2023 |
78 | 93 | Etamsylate 500 mg i.v. every 4 h | |
| Department of Anaestesiology and Intensive Care Medicine | 32 | 67 | ||
| 29 | 64 | |||
| 31 (AEL) | CREP2 | CREJ2 | ||
| Department of Infectious Diseases Department of Urology | 16 January 2023 24 January 2023 29 January 2023 30 January 2023 31 January 2023 01 February 2023 |
119 | 105 | Etamsylate, paracetamol |
| 57 | 102 | |||
| 108 | 212 | |||
| 72 | 178 | |||
| 67 | 140 | |||
| 92 | 108 | |||
| 32 (KIR) | CREP2 | CREJ2 | ||
| Department of Urology | 23 January 2023 24 January 2023 25 January 2023 27 January 2023 29 January 2023 |
113 | 127 | Polymedication including: ampicilin/sulbactam, bisoprolol, enoxaparine, methoclopramide, simeticone, omeprazole, itopride, alopurinol, pantoprazole, rosuvastatine, metformin, rivaroxaban, linesolide, bromazepam |
| 75 | 149 | |||
| 149 | 138 | |||
| 151 | 147 | |||
| 146 | 132 | |||
| 33 (YAV) | CREP2 | CREJ2 | ||
| Department of Urology | 23 January 2023 24 January 2023 25 January 2023 27 January 2023 29 January 2023 |
42 | 141 | Metamizole, etamsylate, paracetamol |
| 75 | 167 | |||
| 105 | 168 | |||
| 117 | 154 | |||
| 111 | 118 | |||
| 34 (LRI) | CREP2 | CREJ2 | ||
| Department of Urology | 16 January 2023 23 January 2023 24 January 2023 25 January 2023 27 January 2023 29 January 2023 |
84 | 69 | Metamizole, etamsylate, paracetamol |
| 90 | 87 | |||
| 46 | 77 | |||
| 66 | 63 | |||
| 50 | 86 | |||
| 77 | 77 | |||
| 35 (SAN) | CREP2 | CREJ2 | ||
| 25 January 2023 (0:35) 25 January 2023 (6:17) |
54 | 83 | ||
| 54 | 75 | |||
| Department of Anaestesiology and Intensive Care Medicine Department of Surgery | 25 January 2023 (8:19) 26 January 2023 27 January 2023 30 January 2023 |
54 | 77 | Etamsylate 500 mg i.v. every 4 h |
| 53 | N/A | |||
| 48 | 57 | |||
| 51 | 60 | |||
| 36 (AAV) | CREP2 | CREJ2 | ||
| Department of Infectious Diseases | 20 January 2023 23 January 2023 25 January 2023 |
133 | 142 | Polymedication including: insuline-lispro, insuline-glargin, perindopril-arginine, linezolid, rosuvastatin, pantoprazol |
| 137 | 134 | |||
| 40 | 115 | |||
| 37 (HAN) | CREP2 | CREJ2 | ||
| Department of Surgery | 15 January 2023 21 January 2023 22 January 2023 23 January 2023 24 January 2023 25 January 2023 27 January 2023 28 January 2023 29 January 2023 30 January 2023 |
142 | 140 | From 21 January 2023: etamsylate 500 mg i.v. every 6 h paracetamol 1 g i.v. every 8 h, noradrenalin continuous |
| 345 | 336 | |||
| 285 | 337 | |||
| 192 | 319 | |||
| 157 | 286 | |||
| 124 | 270 | |||
| 120 | 350 | |||
| 151 | 340 | |||
| 149 | 342 | |||
| 194 | 326 | |||
| 38 (KAV) | CREP2 | CREJ2 | ||
| Department of Anaestesiology and Intensive Care Medicine | 24 January 2023 25 January 2023 26 January 2023 27 January 2023 28 January 2023 29 January 2023 |
153 | 158 | Etamsylate 500 mg i.v. every 4 h, noradrenalin continuous 10 mg / 50 ml i.v., paracetamol 1 g i.v. infusion |
| 145 | 207 | |||
| 239 | N/A | |||
| 179 | 244 | |||
| 145 | 155 | |||
| 127 | 125 | |||
| 39 (BCH) | CREP2 | CREJ2 | ||
| Department of Pulmonary Diseases and Tuberculosis | 23 January 2023 25 January 2023 30 January 2023 |
48 | 61 | Etamsylate |
| 42 | 63 | |||
| 97 | 95 | |||
| 40 (ALA) | CREP2 | CREJ2 | ||
| Department of Surgery | 26 January 2023 27 January 2023 29 January 2023 |
147 | N/A | 27 January 2023: paracetamol 500 mg á every h i.v., etamsylate 500 mg every 4 h |
| 70 | 132 | |||
| 45 | 81 | |||
| 41 (KAV) | CREP2 | CREJ2 | ||
| Department of Gastroenterology Department of Urology | 19 January 2023 23 January 2023 26 January 2023 27 January 2023 28 January 2023 29 January 2023 30 January 2023 |
103 | 98 | Paracetamol, etamsylate, erdosteine |
| 99 | 83 | |||
| 61 | N/A | |||
| 90 | 121 | |||
| 131 | 155 | |||
| 160 | 154 | |||
| 147 | 145 | |||
| 42 (TIR) | CREP2 | CREJ2 | ||
| Department of Internal Medicine and Gastroenterology | 25 January 2023 26 January 2023 27 January 2023 28 January 2023 |
455 | N/A | |
| 541 | N/A | |||
| 410 | 593 | |||
| 500 | 673 | |||
| 29 January 2023 30 January 2023 31 January 2023 01 February 2023 02 February 2023 |
584 | 739 | Not accessible | |
| 649 | 782 | |||
| 625 | 685 | |||
| 494 | 531 | |||
| 569 | 572 | |||
| 43 (AIM) | CREP2 | CREJ2 | ||
| Department of Neurosurgery | 26.01.2023 27.01.2023 31.01.2023 |
73 | N/A | Polymedication including: perindopril-erbumin 4 mg tbl. 1–0-0, omeprazole 20 mg tbl. 1–0-1, dexamethasone 4 mg tbl. 1–0-0, escinum tbl. 2–2-2, nadroparine 0.6 ml s.c. 1x daily |
| 45 | 87 | |||
| 69 | 64 | |||
| 44 (LAS) | CREP2 | CREJ2 | ||
| Department of Internal Medicine, Geriatrics and Practical Medicine | 21 January 2023 23 January 2023 26 January 2023 27 January 2023 (6:20) 27 January 2023 (8:57) 28 January 2023 29 January 2023 30 January 2023 31 January 2023 |
187 | 181 | Paracetamol 500 mg 2–2-2 orally as needed, etamsylate 2amp. iv. every 4 hod. 5–9-13 h, noradrenaline |
| 146 | 145 | |||
| 125 | N/A | |||
| 91 | 157 | |||
| 82 | 155 | |||
| 106 | 167 | |||
| 142 | 177 | |||
| 177 | 196 | |||
| 218 | 220 | |||
| 45 (KES) | CREP2 | CREJ2 | ||
| Department of Otorhinolaryngology | 18 January 2023 19 January 2023 21 January 2023 25 January 2023 27 January 2023 01 February 2023 |
57 | 57 | Not accesible |
| 60 | N/A | |||
| 61 | 62 | |||
| 56 | 44 | |||
| 31 | 53 | |||
| 59 | 68 | |||
| 46 (MAV) | CREP2 | CREJ2 | ||
| Department of Internal Medicine, Geriatrics and Practical Medicine Department of Neurosurgery Department of Infectious Diseases |
23 January 2023 25 January 2023 26 January 2023 27 January 2023 30 January 2023 |
129 | 112 | Paracetamol 500 mg orally 1–1–1 as needed, metamizole 1 g intramuscularly 1–0–1 |
| 134 | N/A | |||
| 102 | N/A | |||
| 74 | 127 | |||
| 151 | 140 | |||
| 47 (AOJ) | CREP2 | CREJ2 | ||
| Department of Urology | 26 January 2023 28 January 2023 01 February 2023 |
179 | N/A | Not accessible |
| 150 | 285 | |||
| 106 | 232 | |||
| 48 (AUB) | CREP2 | CREJ2 | ||
| Department of Trauma Surgery | 28 January 2023 29 January 2023 |
102 | 103 | Metamizole, etamsylate, paracetamol |
| 31 | 89 | |||
| 49 (AAR) | CREP2 | CREJ2 | ||
| Department of Trauma Surgery | 28 January 2023 29 January 2023 |
94 | 95 | Paracetamol 1 g i.v. every 8 h |
| 18 | 93 | |||
| 50 (YAV) | CREP2 | CREJ2 | ||
| Department of Internal Medicine and Gastroenterology | 27 January 2023 28 January 2023 29 January 2023 (6:32) 29 January 2023 (16:54) 30 January 2023 |
305 | 296 | Not accessible |
| 317 | 348 | |||
| 263 | 402 | |||
| 181 | 332 | |||
| 175 | 353 | |||
| 31 January 2023 01 February 2023 02 February 2023 |
206 | 303 | ||
| 217 | 273 | |||
| 263 | 296 | |||
| 51 (KIN) | CREP2 | CREJ2 | ||
| Department of Trauma Surgery | 29 January 2023 30 January 2023 31 January 2023 |
108 | 112 | Etamsylate, paracetamol |
| 39 | 104 | |||
| 33 | 90 | |||
| 52 (LEF) | CREP2 | CREJ2 | ||
| Department of Pulmonary Diseases and Tuberculosis | 28 January 2023 29 January 2023 30 January 2023 31 January 2023 01 February 2023 |
747 | 721 | Etamsylate |
| 646 | 610 | |||
| 151 | 202 | |||
| 81 | 73 | |||
| 66 | 59 | |||
| 53 (AAS) | CREP2 | CREJ2 | ||
| 28 January 2023 29 January 2023 30 January 2023 01 February 2023 02 February 2023 |
100 | 117 | Noradrenalin 10 mg / 50 mL continuous i.v. | |
| Department of Anaestesiology and Intensive Care Medicine | 97 | 109 | ||
| 98 | 146 | |||
| 143 | 183 | |||
| 151 | 154 | |||
| 54 (KIR) | CREP2 | CREJ2 | ||
| Department of Internal Medicine and Gastroenterology | 23 January 2023 25 January 2023 30 January 2023 31 January 2023 01 February 2023 02 February 2023 |
481 | 434 | Paracetamol |
| 477 | 455 | |||
| 407 | 627 | |||
| 527 | 767 | |||
| 635 | 794 | |||
| 732 | 862 | |||
| 55 (YEL) | CREP2 | CREJ2 | ||
| Department of Urology | 30 January 2023 31 January 2023 |
47 | 102 | Metamizole, etamsylate, paracetamol |
| 61 | 90 |
Selection of cases was done on the basis of a 25% fall in preceding creatinine concentrations; data were taken as accessible from medical records.