Table 1.
Clinical and hormonal parameters of different groups of patients.
| Tebuconazole | NW (n = 10) | Obese (n = 10) | PCOS NW (n = 10) | PCOS obese (n = 10) | P-value |
|---|---|---|---|---|---|
| Age | 31.1 ± 1.1ab | 34 ± 1.1a | 29.5 ± 0.9b | 30.4 ± 0.9ab | 0.0188 * |
| BMI (kg/m²) | 21.8 ± 0.6a | 33 ± 0.4b | 20.7 ± 0.5a | 33.3 ± 0.5b | < 0.0001 * ** * |
| Number of follicles | 17.4 ± 1.4a | 9.7 ± 1.2a | 44 ± 4.1b | 31.2 ± 1.3c | < 0.0001 * ** * |
| Cycles | 28.5 ± 0.6a | 29.2 ± 0.7a | 98.5 ± 19.5b | 93.9 ± 17.8b | 0.0001 * ** |
| Testosterone (µg/l) | 0.2 ± 0.1a | 0.2 ± 0.1a | 0.8 ± 0.1b | 0.8 ± 0.1b | < 0.0001 * ** * |
| AMH (ng/ml) | 3 ± 0.5a | 4.6 ± 0.8ac | 17.1 ± 4.9bc | 10.8 ± 1.6c | 0.0007 * ** |
| FSH (UI/L) | 6.8 ± 0.9 | 7 ± 1.1 | 5.3 ± 0.3 | 4.6 ± 0.4 | 0.0333 * |
| LH (UI/L) | 4.1 ± 0.3a | 3.7 ± 0.4a | 8.1 ± 1.2b | 6.1 ± 0.9ab | 0.0011 * * |
| Ratio LH/FSH | 0.7 ± 0.1a | 0.6 ± 0.1a | 1.6 ± 0.2b | 1.4 ± 0.2b | < 0.0001 * ** * |
| Estradiol (ng/l) | 43.3 ± 4.3 | 41.5 ± 5.3 | 41.5 ± 4.2 | 36.8 ± 2.2 | 0.7028 |
| Number of mature ovocytes | 5.8 ± 0.7 | 3.9 ± 0.8 | 7.6 ± 1.2 | 7.3 ± 1.1 | 0.0467 * |
| Number of embryos | 3.4 ± 0.6ab | 2 ± 0.6a | 5.3 ± 0.8b | 4.2 ± 0.7ab | 0.0165 * |
| A. Epoxiconazole | |||||
| NW (n = 10) | Obese (n = 10) |
PCOS NW (n = 10) |
PCOS obese (n = 10) | P-value | |
| Age | 30.92 ± 0.9ab | 33.67 ± 0.6b | 29.62 ± 0.8a | 30.42 ± 0.9a | 0.0054 * * |
| BMI (kg/m²) | 21.58 ± 0.4a | 32.08 ± 0.4b | 20.85 ± 0.3a | 33.08 ± 0.4b | < 0.0001 * ** * |
| Number of follicles | 17.42 ± 1.2a | 9.5 ± 0.9a | 43.23 ± 3.8b | 30.92 ± 1.0c | < 0.0001 * ** * |
| Cycles | 27.17 ± 1.0a | 29.21 ± 0.7a | 103.08 ± 18.5b | 94.92 ± 16.8b | < 0.0001 * ** * |
| Testosterone (µg/l) | 0.13 ± 0.02a | 0.19 ± 0.02a | 0.8 ± 0.1b | 0.77 ± 0.1b | < 0.0001 * ** * |
| AMH (ng/ml) | 3.03 ± 0.4a | 4.59 ± 0.6a | 17.53 ± 4.3b | 10.06 ± 1.4b | < 0.0001 * ** * |
| FSH (UI/L) | 6.63 ± 0.8 | 6.96 ± 0.7 | 5.71 ± 0.3 | 4.81 ± 0.4 | 0.0636 |
| LH (UI/L) | 3.96 ± 0.2a | 3.63 ± 0.3a | 8.7 ± 1.1b | 6.78 ± 0.5b | < 0.0001 * ** * |
| Ratio LH/FSH | 0.66 ± 0.1a | 0.57 ± 0.1a | 1.57 ± 0.1b | 1.48 ± 0.1b | < 0.0001 * ** * |
| Estradiol (ng/l) | 44.75 ± 4.3 | 41.18 ± 4.0 | 42.58 ± 4.3 | 40.24 ± 1.7 | 0.8364 |
| Number of mature ovocytes | 5.83 ± 0.6ab | 3.92 ± 0.5a | 7.62 ± 1.0b | 7.5 ± 0.8b | 0.0034 * * |
| Number of embryos | 3.67 ± 0.4ab | 2.08 ± 0.6a | 4.54 ± 0.6b | 4.17 ± 0.6ab | 0.0232 * |
A) Characteristics of patients for the tebuconazole exposure. B) Characteristics of patients for the epoxiconazole exposure. BMI: body mass index; AMH: anti-Mullerian hormone; FSH: follicular stimulating hormone; LH: luteinizing hormone. Data are mean ± SEM.* p < 0.05, 95% confidence interval; * * p < 0.01, 99% confidence interval; * ** p < 0.001, 99.9% confidence interval; * ** *p < 0.0001, 99.99% confidence interval