Table 1.
Expression levels of H2S-synthesizing enzymes in several oncological phenotypes.
| Type of Cancer | Expression Level of CBS | Expression Level of CSE | Expression Level of 3-MST | Cancer Cell Lines/Cancer Tissues | References |
|---|---|---|---|---|---|
| Colon cancer | High | Low | Variable | Human tissues HCT116 HT29 |
[130,131] |
| Breast cancer | High | High | High | Human tissues | [31,132] |
| Ovarian cancer | High | Low | Not investigated | OV167 OV202 SKOV3 A2780 |
[133] |
| Melanoma | Not altered | High | Not altered | A375 Sk-Mel-5 Sk-Mel-28 PES 43 |
[134] |
| Liver cancer | High | High | Low | HepG2 SMMC-7721 QGY-7703 BEL-7402 BEL-7404 MHCC-LM3 Huh7 Hep3B |
[135,136,137] |
| Lung adenocarcinoma | High | High | High | A549 H522 H1944 |
[138] |
| Bladder cancer | High | High | High | Human tissues | [139] |
| Leukemia | High | Not altered | Not altered | CML-derived K562 cells | [140] |
| Multiple Myeloma | High | Not investigated | Not investigated | Human tissues | [141] |
| Prostate cancer | High | High | Not investigated | LNCap PC3 LNCaP-B |
[142,143,144] |
| Gastric cancer | High | High | Not investigated | SGC-7901 AGS |
[145,146] |
| Renal cancer | High | High | High | RCC4 | [147,148] |
| Glioblastoma | Not investigated | Not investigated | High | C6, U87 |
[37,149,150] |
| Thyroid cancer | High | High | Not investigated | TPC1 TT ARO |
[151,152] |
| Urothelial carcinoma | High | High | High | 5637 UM-UC-3 EJ |
[129,139,147,153] |
| Biliary tract carcinoma | High | Not investigated | Not investigated | GB-H3 GB-D1 TFK-1 HUCCT-1 |
[154] |
| Astrocytoma | Not investigated | Not investigated | High | U373 | [150] |
| Neuroblastoma | Not investigated | Not investigated | High | SH-SY5Y | [155,156] |
| Oral squamous cell carcinoma | High | High | High | OSCC | [157] |