Fig. 8.

Dose-effect functions for the effects of naloxone on ventilation (left panels, from time-effect functions shown in Fig. 7) and on rectal temperature (right panels) when administered alone and when administered 5 minutes after administration of 0.1 mg/kg fentanyl alone (upper panels, replotted from Fig. 6), 0.1 mg/kg fentanyl combined with 0.1 mg/kg d-methamphetamine (upper panels), 3.2 mg/kg heroin alone (lower panels, replotted from Fig. 6), or 3.2 mg/kg heroin combined with 0.1 mg/kg d-methamphetamine (lower panels). See Figs. 2 and 4 for other details (see Table 4 and Supplemental Table 10 for details of statistical analyses).