TABLE 4.
ED80 and slope values (95% CI) for reversal by naloxone of the ventilatory effects of 0.1 mg/kg fentanyl alone, 0.1 mg/kg fentanyl with 0.1 mg/kg d-methamphetamine, 3.2 mg/kg heroin alone, and 3.2 mg/kg heroin with 0.1 mg/kg d-methamphetamine (calculated from data shown in Fig. 8)
Potency and slope ratios represent the values determined with mixtures of d-methamphetamine with fentanyl or heroin divided by values determined with fentanyl or heroin alone, respectively.
| Compound | VE | |
|---|---|---|
| naloxone versus 0.1 mg/kg fentanyl alone | ED80 | 4.39 (3.49, 5.34) |
| Slope | 8.30 (6.67, 9.94) | |
| naloxone versus 0.1 mg/kg fentanyl + 0.1 mg/kg d-methamphetamine | ED80 | 3.39 (0.859, 5.75) |
| ED80 ratio | 0.772 (0.161, 1.65) | |
| Slope | 6.43 (3.40, 9.46) | |
| Slope ratio | 0.775 (0.342, 1.42) | |
| naloxone versus 3.2 mg/kg heroin alone | ED80 | 6.10 (4.51, 8.34) |
| Slope | 5.61 (3.69, 7.54) | |
| naloxone versus 3.2 mg/kg heroin + 0.1 mg/kg d-methamphetamine | ED80 | 6.33 (4.68, 8.76) |
| ED80 ratio | 1.04 (0.561, 1.94) | |
| Slope | 5.22 (3.37, 7.07) | |
| Slope ratio | 0.930 (0.447, 1.92) | |