Table 1.

Biophysical properties of WT and variant hKv3.2-p.Cys125Tyr in HEK-293 cells

Group	Peak current density (at 0 mV)	Voltage dependence of activation (V1/2)	Time constant of activation (at +10 mV)		Time constant of deactivation (at −70 mV)	Resting membrane potential Vm	n
	pA/pF	mV	t (ms)		t (ms)	V 1/2
Kv3.2-WT	106.2 ± 40.2	7.9 ± 1.5	12.0 ± 1.9		2.5 ± 0.1	−32.8 ± 1.7	12
Cys125Tyr	689.2 ± 93.5***	−24.8 ± 1.1***	2.7 ± 0.5*		10.8 ± 0.5***	−64.9 ± 2.2	22
WT + Cys125Tyr	497.6 ± 59.7***	−7.3 ± 2.4***	1.5 ± 0.2***		5.1 ± 0.7**	−62.2 ± 2.0	28

^*P < 0.05;

^**P < 0.01; and

^***P < 0.001; vs. WT via one-way ANOVA.