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. 2024 Jan 12;121(3):e2318989121. doi: 10.1073/pnas.2318989121

Fig. 3.

Fig. 3.

Posterior means versus truth for CTMC generator matrix elements within differing sparsity regimes and with different dimensionalities d, holding observation count fixed at 300. We generate posteriors using surrogate-trajectory HMC with the naive matrix exponential derivative. To affect sparsity levels, we generate generator matrix entries according to the Bayesian bridge distribution (34) with different exponents (α{1,1/2,1/4} for plots A, B and C, respectively), normalizing by the largest absolute values to ease comparison. Smaller α values encode more peaked distributions with heavier tails and thus enforce greater sparsity. Plot C reflects the fact that the Bayesian bridge prior with exponent α=1/4 helps identify non-null parameters in small sample contexts (18). With this intuition in mind, we specify such a prior on generator random effects in Section 3.