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. 2024 Jan 9;121(3):e2315354120. doi: 10.1073/pnas.2315354120

Fig. 5.

Fig. 5.

Intranasal administration of dimeric IgA in hACE2 mice is protective against Omicron BA.5. (A) Experimental design for the evaluation of antibody biodistribution after administration of 60 µg DXP-604 dIgA1 (labeled with Alexa Fluor 647). (B) Representative whole-body images. (C) Representative ex vivo images. N, nasal cavity; Lu, lungs and section of the trachea; H, heart; Li, liver; S, spleen; K, kidney. In (B) and (C), the negative control mice received PBS only. (D) Quantification of fluorescence signals. Data are presented as mean ± SD of five mice (whole-body imaging) or three mice (ex vivo nasal cavity and lung imaging). (E) Experimental design for the evaluation of DXP-604 dIgA1 using therapeutic and prophylactic intranasal administration. (F) Viral loads in the lung and tracheal tissues at 3 d post-infection of Omicron BA.5-infected mice after administration of a single dose of DXP-604 dIgA1 in a therapeutic (60 µg, 2 h post-infection) and prophylactic (40 or 60 µg, 4 h preinfection) setting. Viral loads are expressed as the mean ± SD for three mice. A two-sided unpaired t test was used. *P < 0.05 and **P < 0.01.