Fig. 6.

In vivo verification of IFN-γ promoting the M2 polarization of TAMs and the progression of stage IA NSCLC in mice. A Determination of tumor size, volume, and weight in mice; B CD163 and CD206 expression was detected by Western blot; C: IL-6, IL-10, IL-13 and TNF-α levels were measured by ELISA; D The expression of IDO1 and Ki-67 was detected by immunohistochemistry; E Apoptosis was evaluated by TUNEL staining; F The expression of Bax, Bcl-2 and C-caspase 3 was detected by Western blot. Compared with the NSCLC group, ^* P < 0.05, ^** P < 0.01, ^*** P < 0.001