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. 2024 Jan 22;25:29. doi: 10.1186/s13059-023-03151-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — A Pearson correlation heatmap correlating PICs to measured cell type proportions in the blood. The correlation p-values are corrected for multiple testing with Benjamini-Hochberg, and only correlations with an FDR < 0.05 are shown. B Regression plot showing the correlation between PIC2 and myeloid lineage cell proportions (granulocyte + monocyte) in the blood. C Simplified overview of the blood cell type lineage with annotations of PICs describing distinct (groups of) cell types using measured cell type proportions, gene set enrichments, and single-cell expression enrichment. Positive and negative signs indicate the direction of the effect. Only the first 10 PICs are considered. An image of the top layer cell type is created with BioRender.com. D Negatively correlating eQTL genes interacting with PIC10 showed enrichment for type II interferon signaling as annotated by the Interferome Database Annotation