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Mechanism of heparin blocking SARS-CoV-2 infection in diabetic models
A: IHC assay of HIF-1α in lungs of hACE2-Lepr-/- and hACE2-Lepr+/+ mice treated with heparin after infection. 5×, scale bar represents 300 µm; 20×, scale bar represents 100 µm. B: mRNA levels of CXCL-10, IFN-γ, and IL-1β cytokines in lungs of hACE2-Lepr-/- and hACE2-Lepr+/+ mice treated with heparin by qPCR.
