Figure 3.

Effect of treatment with a sepsis bundle on the odds ratio (OR) of survival (95% CI) in studies grouped based on whether the bundles studied specified that 30 mL/kg fluid be administered, that a volume other than 30 mL/kg be given as shown in the figure, or that did not specify what volume be administered (i.e., an individualized volume) (inverted open triangles). The overall ORs (95% CI) and I2 are shown for each of these three groups (inverted closed triangles). The overall effects of bundles did not differ significantly (p = 0.19) comparing studies requiring 30 mL/kg to all other studies not requiring this volume. This difference was also not significant (p = 0.27) when the one study requiring a fluid volume greater than or equal to 2 L was combined with those requiring 30 mL/kg and compared with all other studies. NS = not significant.