Bundle Group				Control Group
Fluids		Other Interventions
Timing	Volume	Adjunctive Aids	Other
NS	NS	Yes	—	No sepsis alert
≤ 1 hr	NS	Yes	O2 therapy ≤ 1 hr; measure urine output ≤ 1 hr	No bundle
≤ 30 min	≥ 20 mL/kg bolus	Yes	—	No bundle
≤ 1 hr	≥ 20 mL/kg	Yes	VP/I	No bundle
NS	30 mL/kg	Yes	—	No bundle
≤ 30 min	500 mL	No	Hemoglobin of 7–9 g/dL; VP/I	Bundle uncompleted
≤ 2 hr	≥ 2 L	Yes	—	No bundle
NS	30 mL/kg bolus	Yes	—	No bundle
≤ 1 hr	NS	Yes	—	No bundle
≤ 30 min	30 mL/kg bolus	Yes	—	Bundle uncompleted
≤ 30 min	30 mL/kg bolus	Yes	—	Bundle uncompleted
≤ 30 min	30 mL/kg bolus	Yes	—	Bundle uncompleted
≤ 3 hr	30 mL/kg	Yes	—	No bundle
NS	NS	No	VP/I	Bundle uncompleted
≤ 2 hr	1.5–2 L	No	—	Bundle uncompleted
NS	30 mL/kg bolus	No	VP/I	Bundle uncompleted
NS	500–1000 mL bolus, titrate up to 30 mL/kg	Yes	VP/I	No bundle