Table 2.
Univariate Cox Regression Analysis of Risk Factors of Survival in Training Cohort
| Variable | HR | 95% CI | P value |
|---|---|---|---|
| Diabetes | 2.365 | 1.411–3.966 | 0.001 |
| Extrahepatic metastases | 2.655 | 1.676–4.205 | <0.001 |
| Macrovascular invasion | 2.829 | 1.744–4.588 | <0.001 |
| BCLC Staging | |||
| A | REF | ||
| B | 2.629 | 1.350–5.120 | 0.004 |
| C | 7.519 | 3.908–14.464 | <0.001 |
| D | 28.938 | 12.342–67.853 | <0.001 |
| ALT | 1.005 | 1.002–1.008 | 0.001 |
| AST | 1.003 | 1.002–1.005 | <0.001 |
| TP | 0.949 | 0.909–0.990 | 0.016 |
| ALB | 0.968 | 0.938–0.999 | 0.046 |
| ALBI Grade | 1.541 | 1.168–2.032 | 0.002 |
| ALBI Grade | |||
| 1 | REF | ||
| 2 | 1.563 | 0.927–2.636 | 0.094 |
| 3 | 3.252 | 1.676–6.039 | <0.001 |
| TB | 1.003 | 1.002–1005 | <0.001 |
| CRP | 1.017 | 1.009–1.025 | <0.001 |
| LDH | 1.001 | 1.000–1.001 | 0.006 |
| γ-GT | 1.002 | 1.001–1.003 | 0.001 |
| UREA | 1.096 | 1.049–1.146 | <0.001 |
| CRE | 1.007 | 1.002–1.012 | 0.008 |
| MHR | 1.368 | 1.244–1.503 | <0.001 |
| WBC | 1.061 | 1.030–1.092 | <0.001 |
| PLT | 1.002 | 1.000–1.004 | 0.028 |
| Monocyte Count | 4.110 | 1.885–8.957 | <0.001 |
| Neutrophil Count | 1.090 | 1.042–1.139 | <0.001 |
| AFP | |||
| ≤20 | REF | ||
| 20–400 | 1.931 | 0.871–4.280 | 0.105 |
| ≥400 | 1.559 | 1.020–2.381 | 0.040 |
Abbreviations: HR, hazard ratio; CI, confidence interval; BCLC, Barcelona Clinic Liver Cancer; REF, reference; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TP, total protein; ALB, albumin; ALBI, albumin-bilirubin; TB, total bilirubin; CRP, C-reactive protein; LDH, lactate dehydrogenase; γ-GT, gamma-glutamyl transpeptidase; CRE, creatinine; MHR, monocyte -to-HDL ratio; WBC, white blood cell; PLT, platelet; AFP, alpha fetoprotein.