Table 3.
Multivariate Cox Regression Analyses of Risk Factors of Survival in Training Cohort
| Variable | HR | 95% CI | P value |
|---|---|---|---|
| Extrahepatic metastases | 2.014 | 1.077–3.766 | 0.028 |
| Macrovascular invasion | 2.075 | 1.068–4.03 | 0.031 |
| BCLC staging system | |||
| A | REF | ||
| B | 2.369 | 1.091–5.144 | 0.029 |
| C | 4.449 | 1.957–10.114 | <0.001 |
| D | 26.473 | 7.978–87.843 | <0.001 |
| ALBI Grade | |||
| 1 | REF | ||
| 2 | 4.807 | 1.498–15.427 | |
| 3 | 11.687 | 1.625–84.029 | 0.015 |
| CRP | 1.018 | 1.006–1.030 | 0.003 |
| LDH | 0.998 | 0.997–1.004 | 0.003 |
| MHR | 1.491 | 1.240–1.791 | <0.001 |
Abbreviations: HR, hazard ratio; CI, confidence interval; BCLC, Barcelona Clinic Liver Cancer; REF, reference; ALBI, albumin-bilirubin; CRP, C-reactive protein; LDH, lactate dehydrogenase; MHR, monocyte -to-HDL ratio.