Table 2.
Correlations between PFAS Concentration [Log10(X + 1)] in Dogs and each Biomarkera
| biomarker |
N
|
PFAS β (95% CI) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| PFBS | PFHxS | PFHpS | PMPA | PEPA | PFO2HxA | nbp2 | ΣPFAS | ||
| albumin (g/dL) | 29 | 1.03 | −0.22 | −1.03 | −2.30 | −3.26 | −1.43 | 2.74 | −2.30 |
| (−3.13, 5.37) | (−1.10, 0.67) | (−8.52, 6.45) | (−10.64, 6.05) | (−33.03, 26.51) | (−15.78, 12.92) | (−4.79, 10.27) | (−10.64, 6.05) | ||
| alkaline phosphatase (U/L) | 29 | 3.07 | −3.79 b | 21.12 a | −17.58 | 15.39 | −10.49 | −21.46 a | −17.58 |
| (−9.34, 15.47) | (−6.31, −1.27) | (−0.26, 42.50) | (−41.43, 6.27) | (−69.65, 100.43) | (−51.48, 30.51) | (−42.96, 0.04) | (−41.43, 6.27) | ||
| alanine aminotransferase (U/L) | 29 | 10.93 a | −1.33 | 14.31 | 0.84 | 19.78 | 6.59 | −6.21 | 0.84 |
| (0.41, 21.45) | (−3.47, 0.81) | (−3.81, 32.44) | (−10.39, 21.06) | (−52.31, 91.88) | (−28.16, 41.35) | (−24.44, 12.02) | (−19.39, 21.06) | ||
| amylase (U/L) | 29 | 1678.36 | −377.37 | 245.28 | −2453.74 | −5551.19 | −4001.65 | −1669.17 | −2453.74 |
| (−2219.66, 5576.38) | (−1169.45, 414.71) | (−6470.10, 6960.65) | (−9947.19, 5039.71) | (−32,266.75, 21,164.37) | (−16,881.31, 8878.01) | (−8423.44, 5085.10) | (−9947.19, 5039.71) | ||
| total bilirubin (mg/dL) | 24 | 3.95 | −2.27 | 3.09 | −18.19 | 25.63 | −14.86 | −1.16 | −18.19 |
| (−7.43, 15.33) | (−5.82, 1.28) | (−21.47, 27.64) | (−43.90, 7.53) | (−40.76, 92.02) | (−61.31, 31.59) | (−19.83, 17.50) | (−43.90, 7.53) | ||
| blood urea nitrogen (mg/dL) | 29 | 1.39 | 0.42 | −2.89 | −9.65 b | −12.88 | 14.19 b | 0.46 | −9.65 |
| (−2.22, 5.00) | (−0.32, 1.15) | (−9.11, 3.33) | (−16.59, −2.71) | (−37.63, 11.87) | (2.26, 26.13) | (−5.80, 6.71) | (−16.59, −2.71) | ||
| calcium (mg/dL) | 28 | 5.11 | 0.22 | 3.57 | −1.90 | 22.43 | 9.46 | 10.44 | −1.90 |
| (−10.89, 21.10) | (−2.95, 3.38) | (−25.09, 32.22) | (−33.07, 29.27) | (−84.59, 129.45) | (−41.98, 60.91) | (−16.55, 37.44) | (−33.07, 29.27) | ||
| phosphorus (mg/dL) | 29 | −0.81 | −0.23 | 1.80 | −0.66 | −7.23 | −4.93 | −3.63 | −0.66 |
| (−3.94, 2.31) | (−0.86, 0.41) | (−3.59, 7.18) | (−6.67, 5.35) | (−28.65, 14.20) | (−15.26, 5.40) | (−9.05, 1.79) | (−6.67, 5.35) | ||
| creatinine (mg/dL) | 29 | −1.38 | 0.72 | −4.23 | −1.75 | −7.52 | 12.10 | 4.79 | −1.75 |
| (−5.59, 2.84) | (−0.13, 1.58) | (−11.49, 3.03) | (−9.85, 6.35) | (−36.40, 21.35) | (−0.183, 26.02) | (−2.52, 12.08) | (−9.85, 6.35) | ||
| glucose (mg/dL) | 29 | 1.66 | 0.35 | −0.49 | 3.18 | 49.99a | −1.29 | 9.49 | 3.18 |
| (−5.19, 8.52) | (−1.05, 1.74) | (−12.30, 11.31) | (−9.99, 16.35) | (3.03, 96.96) | (−23.94, 21.37) | (−2.38, 21.35) | (−9.99, 16.35) | ||
| sodium (mmol/L) | 29 | −0.04 | 0.00 | 0.39 | 0.29 | −1.89 | 0.27 | −0.14 | 0.29 |
| (−0.34, 0.27) | (−0.06, 0.06) | (−0.14, 0.93) | (−0.31, 0.88) | (−4.01, 0.22) | (−0.75, 1.29) | (−0.67, 0.39) | (−0.31, 0.88) | ||
| potassium (mmol/L) | 20 | 10.29 | −0.27 | 7.51 | −5.69 | −64.57 | 30.57 | −17.47 | −5.69 |
| (−21.32, 41.90) | (−4.37, 3.82) | (−20.53, 35.56) | (−37.59, 26.21) | (−147.09, 17.95) | (−26.34, 87.48) | (−37.70, 2.77) | (−37.59, 26.21) | ||
| total Protein (g/dL) | 29 | 8.65 | 0.69 | −1.45 | 1.02 | −44.83 | 42.09 b | −3.16 | 1.02 |
| (−0.41, 17.71) | (−1.15, 2.54) | (−17.06, 14.16) | (−16.40, 18.44) | (−106.93, 17.27) | (12.16, 72.03) | (−18.86, 12.54) | (−16.40, 18.44) | ||
| globulin (g/dL) | 29 | 7.31 | 0.81 | −0.42 | 3.21 | −43.75 | 43.03 b | −6.26 | 3.21 |
| (−1.07, 15.68) | (−0.89, 2.52) | (−14.85, 14.01) | (−12.89, 19.32) | (−101.16, 13.66) | (15.36, 70.71) | (−20.77, 8.26) | (−12.89, 19.32) | ||
| Albumin/Globulin | |||||||||
| ratio | 29 | −3.37 | −0.23 | −1.46 | −2.38 | 16.89 | −22.28 b | 3.90 | −2.38 |
| (−8.28, 1.53) | (−1.23, 0.76) | (−9.91, 6.99) | (−11.81, 7.05) | (−16.72, 50.51) | (−38.49, −6.08) | (−4.59, 12.40) | (−11.81, 7.05) | ||
a
Data in bold indicate a significant association. Letters indicate p-values with a = p ≤ 0.05 and b = p ≤ 0.01. β represents the beta coefficients and CI represents the 95% confidence intervals.