Figure 4: Increased coverage within and between existing binding sites.

a. A new fragment hit (PDB ID 7GSA, y0288) bridges two fragment-binding hotspots in neighboring allosteric sites from the original cryo fragment hits: the BB site and the L16 site.

b. In another binding site, two new fragment hits (PDB ID 7GTG, y1718; PDB ID 7GSQ, y0847) bind in poses that place chemical groups in regions of the site that were unexplored by the original cryo fragment hits (arrows).