Figure 6: Cross resistance and in vitro selection of parasites.

(A) Plot of EC₅₀ values for two SalA resistant lines (harboring mutations in PRELI domain-containing protein at positions P102L and N145I) for compound 22. Values are plotted as means ± SEMs and statistical significance determined using Mann-Whitney U tests where *p < 0.05.

(B) EC₅₀ shifts of mutant and parental lines against 22. EC₅₀s for each line are presented as means ± SEMs (N, n = 4, 2) and statistical significance determined using Mann-Whitney U tests comparing the parental data vs the mutant line where *p < 0.05.

(C) Summary table of EC₅₀s for each line are presented as means ± SEMs (N, n = 4, 2). EC₅₀s for each line are presented as means ± SEMs (N, n = 4, 2) and statistical significance determined using Mann-Whitney U tests comparing the parental data vs the mutant line where *p < 0.05.