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Endotoxin-induced TNF-α release from PBMCs. The levels of TNF-α after stimulation with 1 ng of LPS (E. coli O55:B5) per ml are given. ○ and ▿, 2 × 106 PBMCs from 15 healthy volunteers with and without MEM-18, respectively; • and ▴, 2 × 106 PBMCs from 13 patients with sepsis with and without MEM-18, respectively; ◊, control with no LPS stimulation.
