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. Author manuscript; available in PMC: 2024 Jan 22.
Published in final edited form as: Cell Chem Biol. 2023 Aug 11;30(11):1421–1435.e12. doi: 10.1016/j.chembiol.2023.07.010

Figure 6. YX968 is highly potent to suppress cancer cell growth.

Figure 6.

(A) Colony formation assays using the indicated cell lines that were exposed to DMSO, YX968, or YX968-NC at the indicated concentrations. Colonies were fixed and stained after treatment. Representative results of four replicates.

(B) Colony formation assays using the indicated cell lines that were exposed to DMSO, RGFP-966, PCI 34051, or a combination (combo) of RGFP-966 + PCI 34051. Representative results of four replicates.

(C) YX968 promotes CASP3 activation. MDA-MB-231 cells were treated with YX968 at the indicated concentrations for 16 h. The cells were also treated with the IAP inhibitor birinapant as a control. The lysates of the treated cells were analyzed by Western blot with antibodies against the indicated proteins. See also Figure S6.