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. Author manuscript; available in PMC: 2024 Jan 22.
Published in final edited form as: Dev Biol. 2021 May 24;477:177–190. doi: 10.1016/j.ydbio.2021.04.010

Figure 4. Shh/Smo signaling promotes ray branching in all paired and unpaired fins.

Figure 4.

Brightfield and fluorescence overlay images of isolated fins from shha:GFP;runx2:mCherry juvenile fish treated with DMSO (A-G) or 1.25 μM BMS-822923 (BMS; H-N) from 21-42 dpf. runx2:mCherry-labeled rays branch (white arrowheads) in all fins whereas rays of BMS-treated fish mostly fail to branch or have severely delayed branching (yellow arrowheads). shha:GFP+ basal epidermal cells are restricted to distal ray tips under both conditions. n=6 for each group. Scale bars are 1 mm.