Table 1. Concentrations (μg/mL) of antibiotics necessary to suppress 16-hour growth of C. difficile in combination with the indicated HDPs.
Antibiotic | No peptide | 2 μM p1 | 2 μM p1Cu | 4 μM p3 | 4 μM p3Cu | 2 μM p1 4 μM p3 |
---|---|---|---|---|---|---|
Vancomycin | 4.000 | 2.000 | 0.0625 | 0.500 | 0.250 | 0.125 |
Metronidazole | 2.000 | 0.500 | 1.0000 | 0.0625 | 1.000 | 0.125 |
Fidaxomicin | 0.256 | 0.0500 | 0.0125 | 0.050 | >0.100 | 0.00625 |
Ciprofloxacin | 128 | n/a | n/a | n/a | n/a | 2.000 |
Antibiotic concentrations are given in μg/ml.