Table 5.
Gene expressions for metallothionein genes in HepG2 cells following Cu NPs or CuCl2 treatment for 72 hr.
| Chemical | Cu NPs | CuCl2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| dosage (μg/ml) | 10 | 5 | 2.5 | 1.25 | 3 | 1 | 0.5 | 0.25 | |
| Metallothionein genes | MT1XP1 | 64 | 116 | 94 | 45 | 66 | nc* | nc | nc |
| MT1X | 68 | 109 | 97 | 33 | 57 | 2.5 | 1.9 | 2.1 | |
| MT1B | 142 | 387 | 168 | 64 | 138 | nc | nc | nc | |
| MT1M | 171 | 340 | 213 | 79 | 198 | nc | nc | nc | |
| MT1G | 204 | 282 | 132 | 50 | 91 | 2.9 | 2.6 | 2.6 | |
| MT1H | 238 | 335 | 291 | 64 | 229 | nc | nc | nc | |
| MT2A | 29 | 33 | 23 | 10 | 16 | 2.0 | nc | 1.5 | |
nc = no change