Table 6:

MicroRNA expression changes (fold change) in HepG2 cells following Cu NPs and CuCl₂ treatment for 72 hr.

chemical		Cu NPs				CuCl2
dosage (μg/ml)		10	5	2.5	1.25	3	1	0.5	0.25
Tumor suppressor
miR-15–16	miR-15b-5p	2	2	1.9	1.4	nc*	nc	nc	nc
	miR-15a-5p	nc	1.8	1.8	nc	nc	nc	nc	nc
	miR-16–5p	1.7	2.3	nc	nc	nc	nc	nc	nc
miR-26	miR-26b-5p	1.9	1.5	nc	2	1.9	1.6	1.8	1.7
	miR-26a-5p	nc	nc	nc	nc	nc	1.3	1.4	1.3
	miR-26a-2	nc	nc	nc	2.1	nc	nc	nc	nc
miR-29	miR-29a-3p	1.8	1.8	nc	1.3	nc	1.4	nc	nc
	miR-29b-3p	2.2	1.7	nc	nc	1.5	nc	nc	nc
miR-122	miR-122–5p	−1.5	−1.5	nc	nc	nc	nc	nc	nc
miR-34	miR34a-5p	2.6	1.8	nc	1.7	1.6	nc	nc	nc
miR-375	mir-375	−2.6	−1.6	nc	−2.4	−2.5	nc	−1.8	−1.9
miR-99a	miR-99a-5p	−1.8	nc	nc	−2.2	−2.3	−1.8	−1.9	−1.6
	miR-146b-5p	−1.8	nc	nc	nc	nc	nc	nc	nc
oncogenic
miR-17–92
miR-17 family	miR-17–5p	1.5	1.6	nc	1.4	1.5	1.7	1.6	1.5
	miR-106a-5p	nc	nc	nc	1.5	1.4	1.8	1.7	1.5
	miR-106b-5p	1.5	1.6	nc	nc	nc	1.5	nc	nc
	miR-93–5p	nc	nc	nc	nc	nc	nc	1.6	nc
miR-92 family	miR-92a-3p	−2.8	−1.9	−1.7	−1.8	−2.5	nc	−1.5	−1.8
	miR-25–3p	−1.8	nc	nc	−1.5	−1.8	nc	nc	−1.5
miR-21	miR-21–5p	−1.6	nc	nc	nc	−1.6	nc	−1.7	nc
miR-221	miR-221–3p	2.2	nc	nc	1.7	nc	nc	1.6	nc
ROS related	miR-210–5p	−2.2	nc	nc	nc	nc	nc	nc	nc

^*nc = no change