Table 8.

Fold changes of mRNA and miRNA in microRNA Target Filter Analyses (in Ingenuity Pathway Analysis) in HepG2 cells following Cu NPs or CuCl₂ treatment for 72 hr.

	chemical	Cu NPs				CuCl2
	dose (μg/ml)	10	5	2.5	1.25	3	1	0.5	0.25
Cu NPs	JUN	2.9	3.2	2.9	2.3	2.1	nc*	nc	Nc
	TGFBR2	−1.5	−1.7	−1.7	−1.3	−1.6	nc	nc	Nc
	FBN1	−2.6	−2.7	−1.7	−1.4	−1.5	nc	nc	Nc
	KITLG	−2.3	−1.8	−1.7	−1.6	−1.7	−1.6	−1.5	−1.6
	HMOX1	70	86	47	2.0	26	nc	nc	Nc
	IGF1R	−1.5	−1.5	−1.3	−1.3	−1.2	nc	nc	Nc
	CIP2A	1.7	2.7	2.1	1.6	2.0	nc	nc	Nc
	SQSTM1	5.1	4.0	3.5	2.0	2.3	nc	nc	1.4
	DNMT3B	4.6	5.2	3.3	1.7	2.4	nc	nc	Nc
	RECK	−2.7	−3.1	−2.1	−1.5	−1.5	nc	nc	Nc
	miR-17–5p	1.5	1.6	nc	1.4	1.5	1.7	1.6	1.5
	miR-146a-5p	3.5	2.0	nc	2.7	2.9	1.8	2.2	2.0
	miR-375–3p	−2.6	−1.6	nc	−2.4	−2.5	nc	−1.8	−1.9
	miR-148a-3p	−1.6	−1.8	nc	−2.1	−1.9	−1.6	−1.7	−1.8
CuCl2	RUNX1	nc	1.4	nc	nc	−1.2	−1.4	−1.3	−1.2
	CHORDC1	2.2	5.3	2.7	nc	2.2	−1.4	−1.4	−1.5
	miR-17–5p	1.5	1.6	nc	1.4	1.5	1.7	1.6	1.5
	miR-26a-5p	1.9	1.5	nc	2.0	1.9	1.6	1.8	1.7

^*nc = no change