Table 9.
Possible mRNA biomarkers for Cu NPs and CuCl2 treatments in HepG2 cells.
| Chemical | Cu NPs | CuCl2 | ||||||
|---|---|---|---|---|---|---|---|---|
| dose (μg/ml) | 10 | 5 | 2.5 | 1.25 | 3 | 1 | 0.5 | 0.25 |
| HMOX-1 | 70 | 87 | 47 | 2.0 | 26 | nc | nc | nc |
| cFOS | 7.1 | 10 | 3.2 | 1.9 | 2.5 | nc | nc | nc |
| GCLM | 7.2 | 10.3 | 6.2 | 2.4 | 4.4 | nc | nc | −1.3 |
| SQSTM1 | 5.1 | 4.0 | 3.5 | 2.0 | 2.3 | nc | nc | 1.4 |
| DNMT3B | 4.6 | 5.2 | 3.3 | 1.7 | 2.4 | nc | nc | nc |
| RECK | −2.7 | −3.1 | −2.1 | −1.5 | −1.5 | nc | nc | nc |
| GADD45G | 105 | 149 | 90 | 28 | nc | nc | nc | nc |
| UCHL1 | 115 | 143 | 59 | 7.8 | nc | nc | nc | nc |
| HSPA6 | >1400 | >3300 | >1000 | 198 | 631 | nc | nc | nc |
| MT1M | 172 | 340 | 213 | 79 | 198 | nc | nc | nc |
*
nc= no change