Table 1.

Summary characteristics of participants with proteomic measures in the Knight ADRC and DIAN cohorts.

Tissue	Status	Sample size (N)	% Female	Age (mean ± SD)
Brain	CO	25	61.72	88.24 ± 8.85
	AD	290	33.33	83.98 ± 8.83
	ADAD	24	76.00	55.67 ± 14.58
	TREM2	21	57.14	82.57 ± 7.62
CSF	CO	494	55.26	73.15 ± 6.43
	AD	176	46.02	74.60 ± 7.02
	TREM2	47	44.68	74.00 ± 6.48
Plasma	CO	254	57.48	71.53 ± 7.31
	AD	105	37.14	72.59 ± 7.67
	TREM2	131	64.89	74.98 ± 8.17

CO = healthy control; AD = sporadic AD cases; ADAD = Autosomal dominant AD; TREM2 = AD-risk variant (p.E151K, p.H157Y, p.L211P, p.R136Q, p.R163Q, p.R47H, p.R62H, p.T96K) carriers in TREM2; CSF = cerebrospinal fluid.