Table 1.

Affinity of MRS 1496 in Radioligand Binding Assay at A₁, A_2A, and A₃ Receptors

ligand	(r)A1 receptora binding affinity Ki (μM)	(r)A2A receptorb binding affinity % displacement (10−4 M)	(h)A3 receptorc binding affinity Ki (μM)
MRS 1496	15.8 ± 1.9	23 ± 10%	0.251 ± 0.028

^aDisplacement of specific [³H]R – PIA binding in rat brain membranes, expressed as K_i ± SEM (n = 4).

^bPercentage of specific binding of [³H]CGS 21680 in rat striatal membranes displaced at the indicated concentration (n = 2).

^cDisplacement of specific [¹²⁵I]AB-MECA binding in membranes of HEK293 cells expressing the human A₃ receptor, expressed as K_i ± SEM (n = 4).