TABLE 2.
Kinetics of white blood cell counts over time according to the response type.
| Total | Pre‐treatment | 2 weeks later | 4 weeks later | 6 weeks later | |
|---|---|---|---|---|---|
| (n = 151) | (n = 138) | (n = 151) | (n = 143) | ||
| White blood count/μL | Mean, (SD) | 6826 (2597) | 7481 (3739) a | 7929 (5170) b | 7690 (5478) a |
| Neutrophils/μL | Mean, (SD) | 4647 (2231) | 5233 (3464) | 5625 (4993) a | 5347 (5282) |
| Neutrophils, % | Mean, (SD) | 66 (9.3) | 67 (11) | 67 (12) b | 66 (13) |
| Lymphocytes/μL | Mean, (SD) | 1440 (581) | 1456 (615) | 1516 (694) | 1498 (667) |
| Lymphocytes, % | Mean, (SD) | 22 (8.7) | 22 (9.5) | 22 (10) | 23 (11) |
| Eosinophils/μL | Mean, (SD) | 179 (187) | 216 (210) b | 218 (246) a | 209 (265) |
| Eosinophils, % | Mean, (SD) | 2.7 (2.5) | 3.3 (3.1) b | 3.3 (3.4) a | 3.3 (3.6) |
| sNLR, ratio | Mean, (SD) | 3.6 (2.0) | 4.3 (3.6) b | 5.2 (7.5) b | 5.5 (10.6) a |
| Responders | (n = 50) | (n = 45) | (n = 50) | (n = 50) | |
|---|---|---|---|---|---|
| White blood count/μL | Mean, (SD) | 6656 (2548) | 6590 (2979) | 6302 (2483) | 6212 (2154) |
| Neutrophils/μL | Mean, (SD) | 4521 (2242) | 4496 (2796) | 3938 (2085) | 3753 (1586) a |
| Neutrophils, % | Mean, (SD) | 66 (10) | 64 (12) | 61 (10) b | 59 (11) b |
| Lymphocytes/μL | Mean, (SD) | 1426 (519) | 1447 (592) | 1620 (618) a | 1686 (695) b |
| Lymphocytes, % | Mean, (SD) | 23 (9.0) | 24 (11) | 27 (8.8) b | 28 (9.6) b |
| Eosinophils/μL | Mean, (SD) | 144 (94) | 175 (138) a | 190 (118) b | 224 (318) |
| Eosinophils, % | Mean, (SD) | 2.5 (1.8) | 3.1 (2.8) | 3.3 (2.1) b | 3.5 (2.9) a |
| sNLR, ratio | Mean, (SD) | 3.6 (2.1) | 3.8 (3.5) | 2.7 (1.6) b | 2.6 (2.0) b |
| Nonresponders | (n = 101) | (n = 93) | (n = 101) | (n = 93) | |
|---|---|---|---|---|---|
| White blood count/μL | Mean, (SD) | 6911 (2630) | 7922 (4005) a | 8735 (5924) b | 8475 (6474) a |
| Neutrophils/μL | Mean, (SD) | 4709 (2234) | 5590 (3706) a | 6459 (5757) b | 6203 (6293) a |
| Neutrophils, % | Mean, (SD) | 67 (8.8) | 68 (10) | 69 (12) b | 70 (13) a |
| Lymphocytes/μL | Mean, (SD) | 1447 (612) | 1460 (629) | 1465 (726) | 1397 (633) |
| Lymphocytes, % | Mean, (SD) | 22 (8.5) | 21 (8.7) b | 20 (10) a | 20 (10) a |
| Eosinophils/μL | Mean, (SD) | 196 (217) | 236 (235) a | 232 (288) | 202 (233) |
| Eosinophils, % | Mean, (SD) | 2.9 (2.8) | 3.4 (3.3) a | 3.3 (3.8) | 3.1 (3.9) |
| sNLR, ratio | Mean, (SD) | 3.7 (2.0) | 4.5 (3.7) b | 6.4 (8.9) b | 7.1 (12.9) b |
Note: Comparisons with pretreatment values were performed with the paired t‐test.
Abbreviations: Responders, patients with a complete or partial response; nonresponders, patients with stable or progressive disease; sNLR, neutrophil‐to‐lymphocyte ratio in serum.
a
p <0.05.
b
p <0.01.