Extended Data Fig. 1. Tumor kinetics.

Fig. 1a shows tumor kinetics in patients who progressed while on therapy per RANO-HGG but continued to receive tovorafenib and who had at least one assessment from a scheduled visit post-PD. Fig. 1b,c show tumor kinetics in patients with best response of progressive disease according to RAPNO and RANO-LGG criteria, respectively. In some patients, who continued therapy due to the absence of a progressive disease assessment per RANO-HGG criteria, an apparent initial increase in tumor size per RAPNO and RANO-LGG criteria was subsequently followed by a sustained decrease in size, suggesting that the initial apparent increase may not represent true progression. HGG, high-grade glioma; LGG, low-grade glioma; PD, progressive disease; RANO, Response Assessment in Neuro-Oncology; RAPNO, Response Assessment in Pediatric Neuro-Oncology.