TABLE 1.

Calculation formulas.

	AEs of interest	All other AEs	Total
Drugs of interest	a	b	a+b
All other drugs in FAERs	c	d	c + d
Total	a+c	b + d	N = a+b + c + d

Note: FAERS: FDA adverse event reporting system; AEs: adverse events.

Reporting odds ratio (ROR) = $\frac{\text{ad}}{\text{bc}}$ .

ROR $95\%\text{CI}={\mathrm{e}}^{\ln \left(\text{ROR}\right)\pm 1.96\sqrt{\left(\frac{1}{\mathrm{a}}+\frac{1}{\mathrm{b}}+\frac{1}{\mathrm{c}}+\frac{1}{\mathrm{d}}\right)}}$

Information components (IC) = ${\mathit{log}}_2\frac{a\left(a+b+c+d\right)}{\left(a+b\right)\left(a+c\right)}$

IC₀₂₅ = ${\mathrm{e}}^{\ln \left(\text{IC}\right)‐1.96\left(\frac{1}{\mathrm{a}}+\frac{1}{\mathrm{b}}+\frac{1}{\mathrm{c}}+\frac{1}{\mathrm{d}}\right)*0.5}$