TABLE 2.
Total | Erenumab | Galcanezumab | Fremanezumab | Eptinezumab | ||||||
---|---|---|---|---|---|---|---|---|---|---|
(n = 65,792) | (n = 38,515) | (n = 19,485) | (n = 5,332) | (n = 2,460) | ||||||
n | % | n | % | n | % | n | % | n | % | |
Sex | ||||||||||
Male | 7,646 | 11.62 | 4,736 | 12.30 | 2,124 | 10.90 | 493 | 9.25 | 293 | 11.91 |
Female | 47,431 | 72.09 | 26,365 | 68.45 | 14,860 | 76.26 | 4,362 | 81.81 | 1,844 | 74.96 |
Unknown | 10,715 | 16.29 | 7,414 | 19.25 | 2,501 | 12.84 | 477 | 8.95 | 323 | 13.13 |
Age (years) | ||||||||||
<18 | 278 | 0.38 | 202 | 0.52 | 43 | 0.22 | 29 | 0.54 | 4 | 0.16 |
18–45 | 12,163 | 11.91 | 7,909 | 20.53 | 2,597 | 13.33 | 1,000 | 18.75 | 657 | 26.71 |
45–65 | 15,456 | 24.58 | 10,689 | 27.75 | 2,643 | 13.56 | 1,112 | 20.86 | 1,012 | 41.14 |
>65 | 5,343 | 6.52 | 4,067 | 10.56 | 632 | 2.25 | 383 | 7.18 | 261 | 9.44 |
Unknown | 32,552 | 56.61 | 15,648 | 40.63 | 13,570 | 69.64 | 2,808 | 52.66 | 526 | 21.38 |
Mean (SD) | 48.66 (14.96) | 49.84 (15.18) | 46.32 (14.42) | 48.19 (15.04) | 49.59 (13.83) | |||||
Reporting year | ||||||||||
2018 | 7,427 | 11.29 | 7,088 | 18.40 | 218 | 1.12 | 121 | 2.27 | 0 | 0 |
2019 | 16,444 | 24.99 | 10,716 | 27.82 | 4,499 | 23.09 | 1,229 | 23.05 | 0 | 0 |
2020 | 15,783 | 23.99 | 8,439 | 21.91 | 6,351 | 32.59 | 869 | 16.30 | 124 | 5.04 |
2021 | 12,131 | 18.44 | 5,629 | 14.62 | 4,408 | 22.62 | 1,359 | 25.49 | 735 | 29.88 |
2022 | 11,240 | 17.08 | 5,335 | 13.85 | 3,305 | 16.96 | 1,387 | 26.01 | 1,213 | 49.31 |
2023 | 2,767 | 4.21 | 1,308 | 3.40 | 704 | 3.61 | 367 | 6.88 | 388 | 15.77 |
Serious outcomes | ||||||||||
Hospitalization | 1,264 | 2.86 | 1,271 | 3.30 | 456 | 2.34 | 289 | 5.42 | 67 | 2.72 |
Disability | 348 | 0.79 | 515 | 1.34 | 160 | 0.82 | 98 | 1.84 | 7 | 0.28 |
Life-threatening | 175 | 0.40 | 209 | 0.54 | 42 | 0.22 | 32 | 0.60 | 6 | 0.24 |
Death | 252 | 0.57 | 296 | 0.77 | 40 | 0.21 | 35 | 0.66 | 9 | 0.37 |
Reported from the United States | 62,721 | 95.33 | 36,436 | 94.60 | 19,151 | 98.29 | 4,703 | 88.20 | 2,431 | 98.82 |