TABLE 4.
Top 30 AEs for four anti-CGRP mAbs.
| Erenmab | Galcanezumab | Fremanezumab | Eptinezumab | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AE | n | % | AE | n | % | AE | n | % | AE | n | % | |
| 1 | Constipation | 2,887 | 17.93 | Injection site pain | 4,079 | 24.37 | Injection site pain | 771 | 13.10 | Fatigue | 147 | 13.54 |
| 2 | Injection site pain | 2,267 | 14.08 | Injection site erythema | 896 | 5.35 | Injection site erythema | 413 | 7.02 | Throat irritation | 98 | 9.02 |
| 3 | Alopecia | 1,164 | 7.23 | Injection site haemorrhage | 831 | 4.97 | Injection site pruritus | 322 | 5.47 | Pruritus | 89 | 8.20 |
| 4 | Injection site haemorrhage | 926 | 5.75 | Injection site pruritus | 676 | 4.04 | Injection site swelling | 262 | 4.45 | Nasal congestion | 81 | 7.46 |
| 5 | Muscle spasms | 625 | 3.88 | Injection site swelling | 663 | 3.96 | Pruritus | 216 | 3.67 | Feeling abnormal | 61 | 5.62 |
| 6 | Feeling abnormal | 542 | 3.37 | Injection site reaction | 595 | 3.56 | Injection site reaction | 193 | 3.28 | COVID-19 | 61 | 5.62 |
| 7 | Injection site bruising | 535 | 3.32 | Alopecia | 582 | 3.48 | Rash | 190 | 3.23 | Hypersensitivity | 56 | 5.16 |
| 8 | Anxiety | 444 | 2.76 | Weight increased | 528 | 3.15 | Alopecia | 182 | 3.09 | Oropharyngeal pain | 45 | 4.14 |
| 9 | Injection site erythema | 437 | 2.71 | Constipation | 495 | 2.96 | Injection site rash | 170 | 2.89 | Rhinorrhoea | 40 | 3.68 |
| 10 | Injection site swelling | 418 | 2.60 | Injection site bruising | 434 | 2.59 | Injection site extravasation | 167 | 2.84 | Nasopharyngitis | 31 | 2.85 |
| 11 | Weight increased | 407 | 2.53 | Pruritus | 389 | 2.32 | Constipation | 159 | 2.70 | Constipation | 31 | 2.85 |
| 12 | Insomnia | 386 | 2.40 | Rash | 381 | 2.28 | Arthralgia | 146 | 2.48 | Memory impairment | 25 | 2.30 |
| 13 | Depression | 338 | 2.10 | Injection site urticaria | 378 | 2.26 | Weight increased | 139 | 2.36 | Chest discomfort | 24 | 2.21 |
| 14 | Myalgia | 317 | 1.97 | Anxiety | 378 | 2.26 | Urticaria | 132 | 2.24 | Infusion site pain | 23 | 2.12 |
| 15 | Influenza like illness | 274 | 1.70 | Feeling abnormal | 355 | 2.12 | Injection site mass | 131 | 2.23 | Flushing | 22 | 2.03 |
| 16 | Injection site reaction | 257 | 1.60 | Injection site mass | 346 | 2.07 | Feeling abnormal | 128 | 2.17 | Anaphylactic reaction | 21 | 1.93 |
| 17 | Urticaria | 253 | 1.57 | Arthralgia | 335 | 2.00 | Anxiety | 122 | 2.07 | Sneezing | 20 | 1.84 |
| 18 | Hypoaesthesia | 253 | 1.57 | Urticaria | 296 | 1.77 | Hypersensitivity | 112 | 1.90 | Infusion related reaction | 19 | 1.75 |
| 19 | Paraesthesia | 252 | 1.57 | Injection site rash | 270 | 1.61 | Injection site urticaria | 109 | 1.85 | Heart rate increased | 17 | 1.57 |
| 20 | Palpitations | 245 | 1.52 | Hypersensitivity | 261 | 1.56 | Injection site bruising | 94 | 1.60 | Throat tightness | 13 | 1.20 |
| 21 | Injection site pruritus | 215 | 1.34 | Insomnia | 203 | 1.21 | Insomnia | 93 | 1.58 | Dry mouth | 13 | 1.20 |
| 22 | Abdominal distension | 181 | 1.12 | Visual impairment | 194 | 1.16 | Injection site haemorrhage | 91 | 1.55 | Hot flush | 12 | 1.10 |
| 23 | Injection site urticaria | 158 | 0.98 | Depression | 187 | 1.12 | Erythema | 85 | 1.44 | Infusion site bruising | 11 | 1.01 |
| 24 | Injection site rash | 134 | 0.83 | Injection site warmth | 177 | 1.06 | Palpitations | 85 | 1.44 | Infusion site extravasation | 9 | 0.83 |
| 25 | Injection site mass | 120 | 0.75 | Myalgia | 148 | 0.88 | Injection site warmth | 76 | 1.29 | Paraesthesia oral | 9 | 0.83 |
| 26 | Injection site extravasation | 109 | 0.68 | Paraesthesia | 135 | 0.81 | Myalgia | 66 | 1.12 | Fibromyalgia | 9 | 0.83 |
| 27 | Injection site indentation | 107 | 0.66 | Hypoaesthesia | 125 | 0.75 | Paraesthesia | 58 | 0.99 | Pharyngeal swelling | 8 | 0.74 |
| 28 | Panic attack | 85 | 0.53 | Memory impairment | 125 | 0.75 | Hypoaesthesia | 56 | 0.95 | Sinus congestion | 8 | 0.74 |
| 29 | Injection site discomfort | 70 | 0.43 | Stress | 120 | 0.72 | Chest pain | 53 | 0.90 | Eye pruritus | 8 | 0.74 |
| 30 | Irritable bowel syndrome | 70 | 0.43 | Palpitations | 120 | 0.72 | Injection site discharge | 52 | 0.88 | Feeling cold | 7 | 0.64 |
Notes: AE, adverse event.