TABLE 5.
AEs co-reported for the four anti-CGRP mAbs.
| Erenumab | Galcanezumab | Fremanezumab | Eptinezumab | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AE | n | % | ROR (95% CI) | n | % | ROR (95% CI) | n | % | ROR (95% CI) | n | % | ROR (95% CI) | |
| 1 | Constipation | 2,887 | 17.93 | 10.32 (9.94,10.72) | 495 | 2.96 | 3.60 (3.30,3.94) | 159 | 2.70 | 2.86 (2.45,3.35) | 31 | 2.85 | 1.77 (1.24,2.52) |
| 2 | Feeling abnormal | 542 | 3.37 | 1.64 (1.51,1.79) | 355 | 2.12 | 2.31 (2.08,2.57) | 128 | 2.17 | 2.07 (1.74,2.46) | 61 | 5.62 | 3.16 (2.45,4.06) |
| 3 | Throat tightness | 46 | 0.29 | 1.36 (1.02,1.81) | 32 | 0.19 | 2.02 (1.43,2.86) | 29 | 0.49 | 4.57 (3.17,6.59) | 13 | 1.20 | 6.53 (3.79,11.26) |
| 4 | Paraesthesia oral | 38 | 0.24 | 2.08 (1.51,2.86) | 16 | 0.10 | 1.87 (1.14,3.05) | 11 | 0.19 | 3.19 (1.77,5.77) | 9 | 0.83 | 8.34 (4.34,16.05) |
| 5 | Alopecia | 1,164 | 7.23 | 3.31 (3.12,3.51) | 582 | 3.48 | 3.53 (3.25,3.83) | 182 | 3.09 | 2.73 (2.36,3.16) | |||
| 6 | Anxiety | 444 | 2.76% | 1.12 (1.02,1.23) | 378 | 2.26% | 2.05 (1.86,2.27) | 122 | 2.07% | 1.64 (1.38,1.97) | |||
| 7 | Weight increased | 407 | 2.53 | 1.37 (1.24,1.51) | 528 | 3.15 | 3.86 (3.54,4.20) | 139 | 2.36 | 2.51 (2.12,2.96) | |||
| 8 | Insomnia | 386 | 2.40 | 1.19 (1.07,1.31) | 203 | 1.21 | 1.34 (1.16,1.53) | 93 | 1.58 | 1.52 (1.24,1.87) | |||
| 9 | Myalgia | 317 | 1.97 | 1.50 (1.34,1.68) | 148 | 0.88 | 1.50 (1.27,1.76) | 66 | 1.12 | 1.66 (1.31,2.12) | |||
| 10 | Influenza like illness | 274 | 1.70 | 2.96 (2.63,3.33) | 75 | 0.45 | 1.72 (1.37,2.16) | 34 | 0.58 | 1.94 (1.39,2.72) | |||
| 11 | Hypoaesthesia | 253 | 1.57 | 1.34 (1.19,1.52) | 125 | 0.75 | 1.42 (1.19,1.69) | 56 | 0.95 | 1.58 (1.22,2.06) | |||
| 12 | Urticaria | 253 | 1.57 | 1.14 (1.01,1.29) | 296 | 1.77 | 2.88 (2.57,3.23) | 132 | 2.24 | 3.19 (2.69,3.79) | |||
| 13 | Paraesthesia | 252 | 1.57 | 1.25 (1.11,1.42) | 135 | 0.81 | 1.44 (1.21,1.70) | 58 | 0.99 | 1.54 (1.19,1.99) | |||
| 14 | Palpitations | 245 | 1.52 | 1.67 (1.47,1.89) | 120 | 0.72 | 1.75 (1.46,2.09) | 85 | 1.44 | 3.09 (2.50,3.83) | |||
| 15 | Abdominal distension | 181 | 1.12 | 1.38 (1.19,1.59) | 104 | 0.62 | 1.69 (1.40,2.05) | 37 | 0.63 | 1.50 (1.08,2.07) | |||
| 16 | Panic attack | 85 | 0.53 | 1.99 (1.61,2.46) | 57 | 0.34 | 2.85 (2.20,3.70) | 34 | 0.58 | 4.23 (3.02,5.93) | |||
| 17 | Fear of injection | 66 | 0.41 | 6.07 (4.76,7.75) | 56 | 0.33 | 11.02 (8.45,14.35) | 12 | 0.20 | 5.79 (3.28,10.21) | |||
| 18 | Menstruation irregular | 53 | 0.33 | 3.32 (2.53,4.35) | 29 | 0.17 | 3.87 (2.69,5.58) | 9 | 0.15 | 2.98 (1.55,5.73) | |||
| 19 | Abnormal dreams | 52 | 0.32 | 2.32 (1.77,3.05) | 29 | 0.17 | 2.77 (1.92,3.98) | 10 | 0.17 | 2.37 (1.27,4.41) | |||
| 20 | Raynaud’s phenomenon | 50 | 0.31 | 8.28 (6.24,10.97) | 35 | 0.21 | 12.31 (8.81,17.21) | 14 | 0.24 | 12.12 (7.16,20.51) | |||
| 21 | Muscle tightness | 42 | 0.26 | 2.10 (1.55,2.84) | 16 | 0.10 | 1.71 (1.04,2.79) | 11 | 0.19 | 2.92 (1.62,5.28) | |||
| 22 | Menstrual disorder | 40 | 0.25 | 3.97 (2.90,5.42) | 20 | 0.12 | 4.22 (2.72,6.56) | 14 | 0.24 | 7.35 (4.35,12.43) | |||
| 23 | Trichorrhexis | 22 | 0.14 | 6.10 (3.99,9.30) | 9 | 0.05 | 5.28 (2.74,10.17) | 6 | 0.10 | 8.74 (3.92,19.51) | |||
| 24 | Hormone level abnormal | 15 | 0.09 | 2.20 (1.32,3.65) | 13 | 0.08 | 4.08 (2.36,7.04) | 5 | 0.08 | 3.89 (1.62,9.37) | |||
| 25 | Oligomenorrhoea | 7 | 0.04 | 3.73 (1.77,7.87) | 4 | 0.02 | 4.55 (1.7,12.16) | 3 | 0.05 | 8.48 (2.73,26.40) | |||
| 26 | Concussion | 36 | 0.22 | 3.32 (2.39,4.61) | 12 | 0.07 | 2.35 (1.33,4.15) | 6 | 0.55 | 9.34 (4.19,20.82) | |||
| 27 | Fibromyalgia | 43 | 0.27 | 1.38 (1.02,1.86) | 24 | 0.14 | 1.65 (1.10,2.46) | 9 | 0.83 | 4.90 (2.55,9.43) | |||
| 28 | Blepharospasm | 31 | 0.19 | 4.90 (3.44,6.99) | 6 | 0.10 | 5.00 (2.24,11.14) | 4 | 0.37 | 10.62 (3.98,28.33) | |||
| 29 | Pruritus | 389 | 2.32 | 1.58 (1.43,1.74) | 216 | 3.67 | 2.19 (1.91,2.50) | 89 | 8.20 | 2.88 (2.34,3.55) | |||
| 30 | Pharyngeal swelling | 22 | 0.13 | 2.20 (1.45,3.35) | 12 | 0.20 | 2.99 (1.70,5.26) | 8 | 0.74 | 6.35 (3.17,12.72) | |||
| 31 | Swollen tongue | 34 | 0.20 | 2.02 (1.44,2.83) | 26 | 0.44 | 3.84 (2.62,5.65) | 6 | 0.55 | 2.82 (1.27,6.29) | |||
Notes: AE: adverse event; ROR: reporting odd ratio; CI: confidence interval.