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. 2023 Jul 7;202(3):1067–1083. doi: 10.1007/s12011-023-03742-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Light photomicrographs of a section of renal cortex from cisplatin-treated group showing a the cortex with distorted renal corpuscles (RC), ballooning of the tubules of the medullary rays (MR), intense cellular infiltration ( ) among the degenerated tubules ( ), and focal areas of proximal tubules with acidophilic cytoplasm (PT). b The medulla shows distorted tubules with multiple hyaline casts within their lumina ( ). Some of the tubules appears dilated (T), and others show obliterated lumen ( ). c The renal corpuscles (RC) appear with shrunken glomerular tuft and pyknotic nuclei ( ). Peritubular cellular infiltration is noticed around the distorted tubules ( ). The proximal convoluted tubules show vaculations ( ), bizzare shaped nuclei of the lining cells ( ), and extruded cells in the lumen with loss of brush border and basophilic cytoplasm ( ). Distorted distal convoluted tubules with flattened cells are seen (DT). d The proximal tubules (PT) show karyolitic nuclei ( ). Some tubules (T) show hyaline casts and exfoliated cells within their lumina ( ). There are peritubular cellular infiltration ( ) and proliferating interstitial fibroblasts ( ). e Renal corpuscle (RC) appears with shrunken glomerular tuft and dark nuclei. Many tubules show severe ballooning (T). Cells of proximal convoluted tubules show vaculations with loss of brush boarder (PT). (H&E. Mic.Mag a, b ×100, c–e ×400)

Inline graphic — Light photomicrographs of a section of renal cortex from cisplatin-treated group showing a the cortex with distorted renal corpuscles (RC), ballooning of the tubules of the medullary rays (MR), intense cellular infiltration ( ) among the degenerated tubules ( ), and focal areas of proximal tubules with acidophilic cytoplasm (PT). b The medulla shows distorted tubules with multiple hyaline casts within their lumina ( ). Some of the tubules appears dilated (T), and others show obliterated lumen ( ). c The renal corpuscles (RC) appear with shrunken glomerular tuft and pyknotic nuclei ( ). Peritubular cellular infiltration is noticed around the distorted tubules ( ). The proximal convoluted tubules show vaculations ( ), bizzare shaped nuclei of the lining cells ( ), and extruded cells in the lumen with loss of brush border and basophilic cytoplasm ( ). Distorted distal convoluted tubules with flattened cells are seen (DT). d The proximal tubules (PT) show karyolitic nuclei ( ). Some tubules (T) show hyaline casts and exfoliated cells within their lumina ( ). There are peritubular cellular infiltration ( ) and proliferating interstitial fibroblasts ( ). e Renal corpuscle (RC) appears with shrunken glomerular tuft and dark nuclei. Many tubules show severe ballooning (T). Cells of proximal convoluted tubules show vaculations with loss of brush boarder (PT). (H&E. Mic.Mag a, b ×100, c–e ×400)