Figure 7.

Summary of the stimulatory and inhibitory effects on human and GM PBMC subsets. Proliferative responses of stimulated T cells and subsets of humans and GMs are shown after 5 days of in-vitro cultivation with ConA (A), PHA (B), and SEB (C) in combination with the four different immunomodulating compounds abatacept (A), belatacept (B), rapamycin (R), and tofacitinib (T). The heatmaps indicate downregulation (blue) or upregulation (red) of proliferative response according to calculated statistical significance shown in Figures 2 – 5 (*p ≤ 0.1, **p ≤ 0.05, ***p ≤ 0.01, ****p ≤ 0.001).